Evidence map›Paper›PMID 28940651›Full record

ReviewGlia2018

Mechanical plasticity during oligodendrocyte differentiation and myelination.

Helena S Domingues, Andrea Cruz, Jonah R Chan, João B Relvas, Boris Rubinstein, Inês Mendes Pinto

Abstract readReview
In one paragraph

Review in Glia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Mechanobiology of Myelin Generation/Regeneration in Health and Disease.Results and problems in cell differentiation · 2026
    Review
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  15. A mechanism-based theory of cellular and tissue plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Review
  17. Myelination dictates axonal viscoelasticity.The European journal of neuroscience · 2023
    Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Helena S DominguesInternational Iberian Nanotechnology Laboratory - INL, Braga, Portugal.ORCID 0000-0003-1230-2682
Andrea CruzInternational Iberian Nanotechnology Laboratory - INL, Braga, Portugal.
Jonah R ChanDepartment of Neurology, University of California, San Francisco, United States of America.
João B RelvasInstituto de Biologia Molecular e Celular - IBMC, Universidade do Porto, Porto, Portugal.
Boris RubinsteinStowers Institute for Medical Research, Kansas City, Missouri, United States of America.
Inês Mendes PintoInternational Iberian Nanotechnology Laboratory - INL, Braga, Portugal.

Funding

THE ESTABLISHMENT OF SCHWANN CELL POLARITY AND THE INITIATION OF MYELINATIONR01NS062796 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHAN, JONAH R · 2008 to 2018
$3.4M
Functional Screening of GPCR Small Molecule Libraries for Remyelination TherapiesR01NS095889 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAN, JONAH R · 2016 to 2020
$1.9M
Somatodendritic Inhibition of Oligodendrocyte MyelinationR01NS097428 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAN, JONAH R, PELES, ELIOR · 2016 to 2020
$1.5M
NINDS NIH HHS R01 NS062796NINDS NIH HHS R01 NS095889NINDS NIH HHS R01 NS097428
6 · The paper itself

Abstract

In the central nervous system, oligodendrocyte precursor cells are exclusive in their potential to differentiate into myelinating oligodendrocytes. Oligodendrocyte precursor cells migrate within the parenchyma and extend cell membrane protrusions that ultimately evolve into myelinating sheaths able to wrap neuronal axons and significantly increase their electrical conductivity. The subcellular force generating mechanisms driving morphological and functional transformations during oligodendrocyte differentiation and myelination remain elusive. In this review, we highlight the mechanical processes governing oligodendrocyte plasticity in a dynamic interaction with the extracellular matrix.

Indexed as

AnimalsCell DifferentiationCell PlasticityCentral Nervous SystemExtracellular MatrixHumansMyelin SheathOligodendrogliacytoskeletonmyelinationoligodendrocyte-extracellular matrix feedback loopsoligodendrocyte mechanics

Identifiers

PMID28940651
PMCPMC5743057

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.