ArticleAging cell2017
Genetic interaction with temperature is an important determinant of nematode longevity.
Article in Aging cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Fmo induction as a tool to screen for pro-longevity drugs.GeroScience · 2024Article
- Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans.Nature communications · 2024Article
- 3-Hydroxyanthranilic Acid Delays Paralysis inBiomolecules · 2024Article
- Article
- The longevity response to warm temperature is neurally controlled via the regulation of collagen genes.Aging cell · 2023Article
- A Compact Imaging Platform for ConductingLife (Basel, Switzerland) · 2023Article
- One-day thermal regime extends the lifespan in Caenorhabditis elegans.Computational and structural biotechnology journal · 2023Article
- C22 disrupts embryogenesis and extendsFrontiers in physiology · 2023Article
- Further Extension of Lifespan byCells · 2022Article
- Article
- Article
- Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.GeroScience · 2020Article
- A mutation that alters the 255th glutamate to lysine in RSKS-1/S6 kinase reliably extends the lifespan ofmicroPublication biology · 2020Article
- HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity.Science advances · 2020Article
- Phenotypic Screening inPharmaceuticals (Basel, Switzerland) · 2020Review
- Article
- Lowbush cranberry acts through DAF-16/FOXO signaling to promote increased lifespan and axon branching in aging posterior touch receptor neurons.GeroScience · 2018Article
- Translational Geroscience: From invertebrate models to companion animal and human interventions.Translational medicine of aging · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
As in other poikilotherms, longevity in C. elegans varies inversely with temperature; worms are longer-lived at lower temperatures. While this observation may seem intuitive based on thermodynamics, the molecular and genetic basis for this phenomenon is not well understood. Several recent reports have argued that lifespan changes across temperatures are genetically controlled by temperature-specific gene regulation. Here, we provide data that both corroborate those studies and suggest that temperature-specific longevity is more the rule than the exception. By measuring the lifespans of worms with single modifications reported to be important for longevity at 15, 20, or 25 °C, we find that the effect of each modification on lifespan is highly dependent on temperature. Our results suggest that genetics play a major role in temperature-associated longevity and are consistent with the hypothesis that while aging in C. elegans is slowed by decreasing temperature, the major cause(s) of death may also be modified, leading to different genes and pathways becoming more or less important at different temperatures. These differential mechanisms of age-related death are not unlike what is observed in humans, where environmental conditions lead to development of different diseases of aging.
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