Evidence map›Paper›PMID 28940621›Full record

ArticleMagnetic resonance in medicine2018

Characterization of the diffusion coefficient of blood.

Carsten Funck, Frederik Bernd Laun, Andreas Wetscherek

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  20. Motion-Induced Signal Loss in In Vivo Cardiac Diffusion-Weighted Imaging.Journal of magnetic resonance imaging : JMRI · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carsten FunckMedical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Frederik Bernd LaunMedical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Andreas WetscherekMedical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Funding

Cancer Research UK 19727Cancer Research UK C33589/A19727
6 · The paper itself

Abstract

purposeTo characterize the diffusion coefficient of human blood for accurate results in intravoxel incoherent motion imaging.

methodsDiffusion-weighted MRI of blood samples from 10 healthy volunteers was acquired with a single-shot echo-planar-imaging sequence at body temperature. Effects of gradient profile (monopolar or flow-compensated), diffusion time (40-100 ms), and echo time (60-200 ms) were investigated.

resultsAlthough measured apparent diffusion coefficients of blood were larger for flow-compensated than for monopolar gradients, no dependence of the apparent diffusion coefficient on the diffusion time was found. Large differences between individual samples were observed, with results ranging from 1.26 to 1.66 µm

conclusionsMeasured blood apparent diffusion coefficient values depend on hematocrit/hemoglobin concentration and applied gradient profile due to non-Gaussian diffusion. Because in vivo measurement is delicate, an estimation based on blood count results could be an alternative. For intravoxel incoherent motion modeling, the use of a blood self-diffusion constant D

Indexed as

Phantoms, ImagingBloodBlood Physiological PhenomenaDiffusionDiffusion Magnetic Resonance ImagingEquipment DesignFemaleHumansMaleModels, Biologicalblooddiffusionflow compensationIVIMMRIperfusion

Identifiers

PMID28940621
PMCPMC5836916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.