Evidence map›Paper›PMID 28940416›Full record

ArticleImmunology2018

Neurotransmitter signalling via NMDA receptors leads to decreased T helper type 1-like and enhanced T helper type 2-like immune balance in humans.

Kanami Orihara, Solomon O Odemuyiwa, William P Stefura, Ramses Ilarraza, Kent T HayGlass, Redwan Moqbel

Open access · bronzeAbstract read
In one paragraph

Article in Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes.Clinical reviews in allergy & immunology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. The N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan Improves Glucose Homeostasis and Preserves Pancreatic Islets in NOD Mice.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2024
    Article
  10. Article
  11. Article
  12. Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function.Handbook of experimental pharmacology · 2022
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kanami OriharaDepartment of Immunology, University of Manitoba, Winnipeg, MB, Canada.
Solomon O OdemuyiwaDivision of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
William P StefuraDepartment of Immunology, University of Manitoba, Winnipeg, MB, Canada.
Ramses IlarrazaDepartment of Immunology, University of Manitoba, Winnipeg, MB, Canada.
Kent T HayGlassDepartment of Immunology, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-4621-7737
Redwan MoqbelDepartment of Immunology, University of Manitoba, Winnipeg, MB, Canada.
University of Alberta · CAUniversity of Manitoba · CA

Funding

CIHR
6 · The paper itself

Abstract

Given the pivotal roles that CD4

Indexed as

CD4-Positive T-LymphocytesCell DeathCell LineCell ProliferationCytokinesHumansInterleukin-10Lymphocyte ActivationNeurotransmitter AgentsReceptors, Antigen, T-CellReceptors, N-Methyl-D-AspartateTh1 CellsTh2 CellsT-Lymphocytes, Helper-InducerUp-RegulationCytokinesInterleukin-10Neurotransmitter AgentsReceptors, Antigen, T-CellReceptors, N-Methyl-D-AspartateCD4+ T cellsglutamateglutamic acidhumanimmune regulationNMDANMDA-RTh1, Th2

Identifiers

PMID28940416
PMCPMC5795186
OpenAlexW2759941852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.