Evidence map›Paper›PMID 28940334›Full record

ArticleMagnetic resonance in medicine2017

Uncovering a third dissolved-phase

Scott H Robertson, Rohan S Virgincar, Elianna A Bier, Mu He, Geoffrey M Schrank, Rose Marie Smigla, Craig Rackley, H Page McAdams, Bastiaan Driehuys

Registry-linked trialAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01280994 (Hyperpolarized 129Xe MR Imaging of the Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01280994 phase2recruitingnot on this map

Hyperpolarized 129Xe MR Imaging of the Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

TypeinterventionalSponsorBastiaan DriehuysRan2011 to 2030Enrolled445ConditionsInterstitial Lung DiseaseArmsHyperpolarized 129Xenon Gas
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. A thermally polarized, dissolved-phaseJournal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
  5. Article
  6. In vivo methods and applications of xenon-129 magnetic resonance.Progress in nuclear magnetic resonance spectroscopy · 2021
    Review
  7. Article
  8. A thermally polarizedMagnetic resonance in medicine · 2019
    Article
  9. Review
  10. Article
  11. HyperpolarizedMagnetic resonance in medicine · 2018
    Article
  12. Article
  13. Article
  14. Hyperpolarized gas MRI in pulmonology.The British journal of radiology · 2018
    Review
  15. Depolarization of nuclear spin polarizedJournal of magnetic resonance (San Diego, Calif. : 1997) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Scott H RobertsonCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, USA.
Rohan S VirgincarCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, USA.
Elianna A BierCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, USA.
Mu HeCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, USA.
Geoffrey M SchrankCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, USA.
Rose Marie SmiglaDivision of Pulmonary, Allergy and Critical Care, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Craig RackleyDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, USA.
H Page McAdamsDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, USA.
Bastiaan DriehuysCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, USA.

Funding

INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRIR01HL105643 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2011 to 2026
$6.7M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
NHLBI NIH HHS R01 HL105643NHLBI NIH HHS R01 HL126771NIBIB NIH HHS P41 EB015897
6 · The paper itself

Abstract

purposeThe purpose of this work was to accurately characterize the spectral properties of hyperpolarized

methodsSubjects underwent hyperpolarized

resultsThree dissolved-phase resonances, consisting of red blood cells (RBCs) and two barrier compartments, were consistently identified in all subjects. In subjects with IPF relative to healthy volunteers, the RBC frequency was 0.70 parts per million (ppm) more negative (P = 0.05), the chemical shift of barrier 2 was 0.6 ppm more negative (P = 0.009), the line widths of both barrier peaks were ∼2 ppm narrower (P < 0.001), and the starting phase of barrier 1 was 20.3 ° higher (P =  0.01). Moreover, the ratio RBC:barriers was reduced by 52.9% in IPF (P < 0.001).

conclusionsThe accurate decomposition of

Indexed as

AdultAgedFemaleHumansIdiopathic Pulmonary FibrosisLungMagnetic Resonance ImagingMaleMiddle AgedSignal Processing, Computer-AssistedXenon IsotopesYoung AdultXenon Isotopeshyperpolarized 129Xeidiopathic pulmonary fibrosisIPFspectroscopy

Identifiers

PMID28940334
PMCPMC5422139

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.