Evidence map›Paper›PMID 28940314›Full record

ArticleThe Journal of physiology2017

Dietary sodium induces a redistribution of the tubular metabolic workload.

Khalil Udwan, Ahmed Abed, Isabelle Roth, Eva Dizin, Marc Maillard, Carla Bettoni, Johannes Loffing, Carsten A Wagner, Aurélie Edwards, Eric Feraille

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Claudin-3 is expressed at theFrontiers in physiology · 2026
    Article
  6. Article
  7. Flow-dependent transport processes 2024: filtration, absorption, and secretion.American journal of physiology. Renal physiology · 2025
    Article
  8. Cyclosporin-induced hypertension is associated with the up-regulation of Na+-K+-2Cl- cotransporter (NKCC2).Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Article
  9. Article
  10. Molecular Physiological Evidence for the Role of NaInternational journal of molecular sciences · 2023
    Article
  11. Article
  12. Review
  13. Directing two-way traffic in the kidney: A tale of two ions.The Journal of general physiology · 2022
    Article
  14. Review
  15. Renal blood flow and oxygenation.Pflugers Archiv : European journal of physiology · 2022
    Review
  16. Dietary sodium intake does not alter renal potassium handling and blood pressure in healthy young males.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
    Article
  17. Article
  18. High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  19. Local and downstream actions of proximal tubule angiotensin II signaling on NaAmerican journal of physiology. Renal physiology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Khalil UdwanDepartment of Cellular Physiology and Metabolism, University of Geneva, CMU, 1 Rue Michel-Servet, CH-1211, Geneva 4, Switzerland.ORCID 0000-0002-6488-2757
Ahmed AbedDepartment of Cellular Physiology and Metabolism, University of Geneva, CMU, 1 Rue Michel-Servet, CH-1211, Geneva 4, Switzerland.
Isabelle RothDepartment of Cellular Physiology and Metabolism, University of Geneva, CMU, 1 Rue Michel-Servet, CH-1211, Geneva 4, Switzerland.
Eva DizinDepartment of Cellular Physiology and Metabolism, University of Geneva, CMU, 1 Rue Michel-Servet, CH-1211, Geneva 4, Switzerland.
Marc MaillardCentre hospitalier universitaire Vaudois, Service de néphrologie, CH-1011, Lausanne, Switzerland.ORCID 0000-0001-6428-0046
Carla BettoniInstitute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.
Johannes LoffingInstitute of Anatomy, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.
Carsten A WagnerInstitute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.
Aurélie EdwardsCentre de Recherche des Cordeliers, INSERM UMRS1138 and CNRS ERL8228, 15 rue de l'Ecole de Médecine, F-75006, Paris, France.
Eric FerailleDepartment of Cellular Physiology and Metabolism, University of Geneva, CMU, 1 Rue Michel-Servet, CH-1211, Geneva 4, Switzerland.ORCID 0000-0003-1656-8365
University of Geneva · CHUniversity of Zurich · CHBoston University · USUniversity Hospital of Lausanne · CHZHAW Zurich University of Applied Sciences · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key pointsBody Na ABSTRACT: Na

Indexed as

Renal EliminationRenal ReabsorptionAdaptation, PhysiologicalAnimalsGlomerular Filtration RateKidney Tubules, ProximalMaleMiceMice, Inbred C57BLOxygenSodium, DietaryOxygenSodium, Dietarydietary saltdiureticsNa+ transportNa+ transportersoptimal Na+ diet

Identifiers

PMID28940314
PMCPMC5685825
OpenAlexW2760651017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.