Evidence map›Paper›PMID 28940301›Full record

Trial reportCancer2018

Randomized trial of Tibetan yoga in patients with breast cancer undergoing chemotherapy.

Alejandro Chaoul, Kathrin Milbury, Amy Spelman, Karen Basen-Engquist, Martica H Hall, Qi Wei, Ya-Chen Tina Shih, Banu Arun, Vicente Valero, George H Perkins and 6 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04172350 (Developing and Examining Preliminary Effects of An Innovative Care-improvement Smartphone-based Perioperative Solution for Women Undergoing Breast Cancer Surgery), which is not on this map. Cited by 54 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 23 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04172350 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Developing and Examining Preliminary Effects of An Innovative Care-improvement Smartphone-based Perioperative Solution for Women Undergoing Breast Cancer Surgery (iCareBreast): A Pilot Randomized Controlled Trial

TypeinterventionalSponsorHE Hong-GuRan2019 to 2021Enrolled112ConditionsBreast Cancer Female, SurgeryArmsiCareBreast, Routine care
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 23 syntheses or guidelines pooled it.

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  4. Yoga for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
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  13. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alejandro ChaoulDepartment of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Kathrin MilburyDepartment of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Amy SpelmanDepartment of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Karen Basen-EngquistDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Martica H HallDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Qi WeiDepartment of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Ya-Chen Tina ShihDepartment of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Banu ArunDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Vicente ValeroDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
George H PerkinsDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Gildy V BabieraDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Tenzin WangyalLigmincha Institute, Shipman, Virginia.
Rosalinda EngleDepartment of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Carol A HarrisonDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Yisheng LiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Lorenzo CohenDepartment of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID http://orcid.org/0000-0003-4372-9208

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Effects of Tibetan Yoga on Fatigue and Sleep in CancerR01CA105023 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI COHEN, LORENZO · 2006 to 2011
$2.5M
Couple-Based Mind-Body Program for Lung Cancer Patients and their PartnersK01AT007559 · NCCIH · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILBURY, KATHRIN · 2013 to 2017
$652k
NCCIH NIH HHS K01 AT007559NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA105023
6 · The paper itself

Abstract

backgroundThe current randomized trial examined the effects of a Tibetan yoga program (TYP) versus a stretching program (STP) and usual care (UC) on sleep and fatigue in women with breast cancer who were undergoing chemotherapy.

methodsWomen with stage (American Joint Committee on Cancer (AJCC) TNM) I to III breast cancer who were undergoing chemotherapy were randomized to TYP (74 women), STP (68 women), or UC (85 women). Participants in the TYP and STP groups participated in 4 sessions during chemotherapy, followed by 3 booster sessions over the subsequent 6 months, and were encouraged to practice at home. Self-report measures of sleep disturbances (Pittsburgh Sleep Quality Index), fatigue (Brief Fatigue Inventory), and actigraphy were collected at baseline; 1 week after treatment; and at 3, 6, and 12 months.

resultsThere were no group differences noted in total sleep disturbances or fatigue levels over time. However, patients in the TYP group reported fewer daily disturbances 1 week after treatment compared with those in the STP (difference, -0.43; 95% confidence interval [95% CI], -0.82 to -0.04 [P = .03]) and UC (difference, -0.41; 95% CI, -0.77 to -0.05 [P = .02]) groups. Group differences at the other time points were maintained for TYP versus STP. Actigraphy data revealed greater minutes awake after sleep onset for patients in the STP group 1 week after treatment versus those in the TYP (difference, 15.36; 95% CI, 7.25-23.48 [P = .0003]) and UC (difference, 14.48; 95% CI, 7.09-21.87 [P = .0002]) groups. Patients in the TYP group who practiced at least 2 times a week during follow-up reported better Pittsburgh Sleep Quality Index and actigraphy outcomes at 3 months and 6 months after treatment compared with those who did not and better outcomes compared with those in the UC group.

conclusionsParticipating in TYP during chemotherapy resulted in modest short-term benefits in sleep quality, with long-term benefits emerging over time for those who practiced TYP at least 2 times a week. Cancer 2018;124:36-45. © 2017 American Cancer Society.

Indexed as

YogaActigraphyAdultAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsChemotherapy, AdjuvantCyclophosphamideDocetaxelDoxorubicinEpirubicinFatigueFemaleFluorouracilHumansMaleAntineoplastic AgentsCyclophosphamideDocetaxelDoxorubicinEpirubicinFluorouracilTaxoidsbreast cancerchemotherapypatientssleep qualityTibetan yoga

Identifiers

PMID28940301
PMCPMC5735004

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.