ArticleThe Laryngoscope2018
Tobacco exposure and wound healing in head and neck surgical wounds.
Article in The Laryngoscope, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 67 citations in OpenAlex.
- Postoperative Complications After Lung Cancer Resection in Patients with a Previous History of Head and Neck Cancer.Cancers · 2026Article
- Identifying Venous Insufficiency in Head and Neck Reconstruction Flaps Using Machine Learning and Deep Learning Methods.Head & neck · 2026Article
- Article
- Human Wound Healing Ex Vivo Model with Focus on Molecular Markers.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Comorbid depression is associated with non-routine discharge following treatment of unruptured cerebral aneurysms.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2025Article
- Distinct Molecular Mechanisms in Oral Mucosal Wound Healing: Translational Insights and Future Directions.International journal of molecular sciences · 2025Review
- Risk factors leading to the formation of intranasal synechiae (adhesions) in patients who underwent septo- and septoturbinoplasty (a retrospective cohort Study).Annals of medicine and surgery (2012) · 2025Article
- Biological processes and factors involved in soft and hard tissue healing.Periodontology 2000 · 2025Review
- A Comprehensive Analysis of Tobacco Smoking History as a Risk for Outcomes after Endoscopic Transsphenoidal Resection of Pituitary Adenoma.Journal of neurological surgery. Part B, Skull base · 2024Article
- Examining the Association between Abstinence from Smoking and Healthcare Costs among Patients with Cancer.Cancer prevention research (Philadelphia, Pa.) · 2024Article
- Epidemiological characteristics and factors influencing hospitalization burden among trauma patients: a retrospective analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Enhanced recovery after surgery, current, and future considerations in head and neck cancer.Laryngoscope investigative otolaryngology · 2023Review
- Alginate-Based Materials Loaded with Nanoparticles in Wound Healing.Pharmaceutics · 2023Review
- Wound fluid sampling methods for proteomic studies: A scoping review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Flap failure prediction in microvascular tissue reconstruction using machine learning algorithms.World journal of clinical cases · 2022Article
- Risk factors for wound-related complications after microvascular decompression.Neurosurgical review · 2021Observational
- No Difference in Functional Outcome but Higher Revision Rate Among Smokers Undergoing Cervical Artificial Disc Replacement: Analysis of a Spine Registry.International journal of spine surgery · 2020Article
- Complications of Mandibular Fracture Repair and Secondary Reconstruction.Seminars in plastic surgery · 2020Review
- Association of Smoking Tobacco With Complications in Head and Neck Microvascular Reconstructive Surgery.JAMA facial plastic surgery · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveSmoking impairs wound healing, yet the underlying pathophysiological mechanisms are unclear. We evaluated tobacco-altered healing in head and neck surgery by studying the association between biomarkers and tobacco exposure, as well as cutaneous perfusion by smoking status. STUDY
designProspective cohort study, tertiary/academic care center, 2011 to present.
methodsPatients who required head and neck surgery were enrolled prospectively. Postsurgical drain fluid was collected 24 hours postoperatively. Biomarkers associated with postulated mechanisms of smoking-impaired healing were assayed. These included interleukin-1, -6, and -8; tumor necrosis factor- alpha; transforming growth factor-beta; epidermal growth factor (EGF); basic fibroblastic growth factor (bFGF); C-reactive protein; vascular endothelial growth factor; soluble FMS-like tyrosine kinase-1 (sFLT-1); and placental growth factor. Tobacco exposure and clinical outcomes were recorded. Two sample two-sided t tests evaluated the differences in cytokine levels by tobacco exposure. In a second cohort, cutaneous vascular assessment via indocyanine green angiography was compared by smoking status.
resultsTwenty-eight patients were enrolled with drain fluid collection. Twenty-one subjects were current/former smokers, whereas seven were never smokers. EGF was higher in never smokers than smokers in a statistically significant manner (P = 0.030). Likewise, sFLT-1 was significantly higher in never smokers (P = 0.011). Cutaneous angiography revealed nonsmokers to have significantly higher cutaneous perfusion than smokers.
conclusionIn this head and neck surgical cohort, significantly higher EGF and sFLT-1 levels in wound fluid were associated with never smoking, suggesting that smoking has adverse effects on the inflammatory phase of wound healing. Cutaneous angiography supports the detrimental effect of smoking on skin perfusion. These findings suggest the need for further study as well as therapeutic targets for smokers undergoing surgery. LEVEL OF EVIDENCE: 2b. Laryngoscope, 128:618-625, 2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.