Evidence map›Paper›PMID 28940248›Full record

ArticleJournal of the American Geriatrics Society2017

Can a Left Ventricular Assist Device in Individuals with Advanced Systolic Heart Failure Improve or Reverse Frailty?

Mathew S Maurer, Evelyn Horn, Alex Reyentovich, Victoria Vaughan Dickson, Sean Pinney, Deena Goldwater, Nathan E Goldstein, Omar Jimenez, Sergio Teruya, Jeff Goldsmith and 3 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02156583 (Frailty), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02156583 completednot on this map

Frailty: Prevalence and Response to Left Ventricular Assist Device Therapy in Older Heart Failure Patients

TypeobservationalSponsorThomas Jefferson UniversityRan2014 to 2017Enrolled20ConditionsSystolic Heart Failure
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Cardiac Surgery in Advanced Heart Failure.Journal of clinical medicine · 2022
    Review
  17. Article
  18. Contrast-Enhanced Ultrasound of Muscle Perfusion May Indicate Patient Response to Left Ventricular Assist Device Therapy.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

Mathew S MaurerClinical Cardiovascular Research Laboratory for the Elderly, Columbia University Medical Center, Allen Hospital of New York Presbyterian, New York, New York.
Evelyn HornWeill Medical College of Cornell University, New York, New York.
Alex ReyentovichNew York University Langone Medical Center, New York, New York.
Victoria Vaughan DicksonNew York University, Meyers College of Nursing, New York, New York.
Sean PinneyIcahn School of Medicine at Mount Sinai, New York, New York.
Deena GoldwaterCedars-Sinai Medical Center, Los Angeles, California.
Nathan E GoldsteinDepartment of Geriatrics, Mount Sinai School of Medicine, New York, New York.
Omar JimenezClinical Cardiovascular Research Laboratory for the Elderly, Columbia University Medical Center, Allen Hospital of New York Presbyterian, New York, New York.
Sergio TeruyaMedicine, Columbia University, New York, New York.
Jeff GoldsmithBiostatistics, Columbia University, New York, New York.
Stephen HelmkeClinical Cardiovascular Research Laboratory for the Elderly, Columbia University Medical Center, Allen Hospital of New York Presbyterian, New York, New York.
Melana YuzefpolskayaClinical Cardiovascular Research Laboratory for the Elderly, Columbia University Medical Center, Allen Hospital of New York Presbyterian, New York, New York.
Gordon R ReevesThomas Jefferson University, Philadelphia, Pennsylvania.
Allen Hospital · USColumbia University · USIcahn School of Medicine at Mount Sinai · USCedars-Sinai Medical Center · USColumbia University Irving Medical Center · USCornell University · USNewYork–Presbyterian Hospital · USNew York University · USNYU Langone Health · USThomas Jefferson University · US

Funding

Midcareer Mentoring Award for Patient Oriented Research in Geriatric CardiologyK24AG036778 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAURER, MATHEW S · 2010 to 2020
$1.6M
Can Ventricular Assist Devices Reverse the Frailty PhenotypeR21AG046703 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HORN, EVELYN, MAURER, MATHEW S · 2014 to 2015
$461k
NIA NIH HHS K24 AG036778NIA NIH HHS R21 AG046703
6 · The paper itself

Abstract

BACKGROUND/

objectivesFrailty, characterized by low physiological reserves, is strongly associated with vulnerability to adverse outcomes. Features of frailty overlap with those of advanced heart failure, making a distinction between them difficult. We sought to determine whether implantation of a left ventricular assist device (LVAD) would decrease frailty.

designProspective, cohort study.

settingFive academic medical centers.

participantsFrail individuals (N = 29; mean age 70.6 ± 5.5, 72.4% male). MEASUREMENTS: Frailty, defined as having 3 or more of the Fried frailty criteria, was assessed before LVAD implantation and 1, 3, and 6 months after implantation. Other domains assessed included quality of life, using the Kansas City Cardiomyopathy Questionnaire; mood, using the Patient Health Questionnaire; and cognitive function, using the Trail-Making Test Part B.

resultsAfter 6 months, three subjects had died, and one had undergone a heart transplant; of 19 subjects with serial frailty measures, the average number of frailty criteria decreased from 3.9 ± 0.9 at baseline to 2.8 ± 1.4 at 6 months (P = .003). Improvements were observed after 3 to 6 months of LVAD support, although 10 (52.6%) participants still had 3 or more Fried criteria, and all subjects had at least one at 6 months. Changes in frailty were associated with improvement in QOL but not with changes in mood or cognition. Higher estimated glomerular filtration rate at baseline was independently associated with a decrease in frailty.

conclusionFrailty decreased in approximately half of older adults with advanced heart failure after 6 months of LVAD support. Strategies to enhance frailty reversal in this population are worthy of additional study.

Indexed as

Frail ElderlyActivities of Daily LivingAgedAged, 80 and overCardiac Surgical ProceduresCohort StudiesFemaleHeart-Assist DevicesHeart Failure, SystolicHumansMalePrognosisProspective StudiesVentricular Dysfunction, Leftadvanced heart failurefrailtyventricular assist device

Identifiers

PMID28940248
PMCPMC5681378
OpenAlexW2756629421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.