Evidence map›Paper›PMID 28940167›Full record

ArticleImmunologic research2018

Th2-biased immune response and agglutinating antibodies generation by a chimeric protein comprising OmpC epitope (323-336) of Aeromonas hydrophila and LTB.

Mahima Sharma, Pujarini Dash, Pramod K Sahoo, Aparna Dixit

Abstract read
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Article in Immunologic research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mahima SharmaGene Regulation Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.
Pujarini DashFish Health Management Division, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar, 751002, India.
Pramod K SahooFish Health Management Division, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar, 751002, India.
Aparna DixitGene Regulation Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India. adixit7@gmail.com.ORCID 0000-0001-9761-7768
Central Institute of Freshwater Aquaculture · INJawaharlal Nehru University · IN

Funding

Institutional grant to JNU under BUILDER programme of the Department of Biotechnology , Ministry of Science and Technology (IN) # BT/PR5006/INF/22/153/2012PURSE grant from the Department of Science and Technology (PURSE grant), New Delhi, India PURSE grant # SR/PURSE/Phase 2/11(C)/2015
6 · The paper itself

Abstract

Aeromonas hydrophila is responsible for causing fatal infections in freshwater fishes. Besides chemical/antibiotic treatment and whole-cell vaccine, no subunit vaccine is currently available for A. hydrophila. Outer membrane proteins of gram-negative bacteria have been reported as effective vaccine candidates. Peptide antigens elicit focused immune responses against immunodominant stretches of the antigen. We have attempted to characterize the immunogenicity of linear B-cell epitopes of outer membrane protein (OmpC) of A. hydrophila identified using in silico tools, in conjugation with heat-labile enterotoxin B (LTB) subunit of Escherichia coli as a carrier protein. Antisera against the fusion protein harboring 323-336 residues of the AhOmpC (raised in mice) showed maximum cross-reactivity with the parent protein OmpC and LTB. The fusion protein displayed efficient GM

Indexed as

Aeromonas hydrophilaAnimalsAntibodies, BacterialBacterial ToxinsBacterial VaccinesCells, CulturedComputers, MolecularCyprinidaeEnterotoxinsEpitopes, B-LymphocyteEscherichia coli ProteinsFish DiseasesGangliosidosis, GM1Gram-Negative Bacterial InfectionsPorinsProtein BindingAntibodies, BacterialBacterial ToxinsBacterial VaccinesEnterotoxinsEpitopes, B-LymphocyteEscherichia coli Proteinsheat-labile enterotoxin, E coliOmpC proteinPorinsRecombinant Fusion ProteinsVaccines, SubunitAeromonas hydrophilaAgglutinationB cellEpitopeLTBOmpC

Identifiers

PMID28940167
OpenAlexW2758533397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.