Evidence map›Paper›PMID 28940148›Full record

ReviewSports medicine (Auckland, N.Z.)2018

Physical Activity in Preventing Alzheimer's Disease and Cognitive Decline: A Narrative Review.

Stefano Brini, Hamid R Sohrabi, Jeremiah J Peiffer, Mira Karrasch, Heikki Hämäläinen, Ralph N Martins, Timothy J Fairchild

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Stefano BriniSchool of Psychology and Exercise Science, Murdoch University, Room 2.042, Social Sciences Building, 90 South Street, Murdoch, Perth, WA, 6150, Australia.
Hamid R SohrabiSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Jeremiah J PeifferSchool of Psychology and Exercise Science, Murdoch University, Room 2.042, Social Sciences Building, 90 South Street, Murdoch, Perth, WA, 6150, Australia.
Mira KarraschDepartment of Psychology, Åbo Akademi University, Turku, Finland.
Heikki HämäläinenDepartment of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland.
Ralph N MartinsSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Timothy J FairchildSchool of Psychology and Exercise Science, Murdoch University, Room 2.042, Social Sciences Building, 90 South Street, Murdoch, Perth, WA, 6150, Australia. T.Fairchild@murdoch.edu.au.
Murdoch University · AUÅbo Akademi University · FIAustralian Alzheimer’s Research Foundation · AUEdith Cowan University · AUUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large body of epidemiological and experimental data exploring the relationship between physical activity (PA) and Alzheimer's disease (AD) are now available. Despite observational evidence supporting a role for PA in delaying the onset of AD, randomised controlled trials have reported mixed findings, likely due to the heterogeneity in study cohorts, outcome measures, and the adopted PA intervention. The primary objective of this narrative review is to evaluate the extant evidence on the relationship between PA, cognitive decline and AD in older populations. The interaction between PA and the putative mechanisms underlying AD progression, including genetic factors and amyloid-β levels will be explored. In this context, particular attention will be given to studies assessing PA in the early clinical and preclinical, asymptomatic stages of AD. Based on current evidence, clinical considerations for implementation of exercise-based interventions are discussed, along with limitations of previous research and directions for future studies.

Indexed as

ExerciseAlzheimer DiseaseCognitive DysfunctionDisease ProgressionExercise TherapyHumans

Identifiers

PMID28940148
OpenAlexW2758712257

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.