SynthesisNeuropsychology review2017
Diagnostic Accuracy of Memory Measures in Alzheimer's Dementia and Mild Cognitive Impairment: a Systematic Review and Meta-Analysis.
Synthesis in Neuropsychology review, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Task-based fMRI brain activation in mild cognitive impairment and Alzheimer's disease: an ALE meta-analysis.GeroScience · 2026Pooled it
- Psychometric Properties of Computerized Cognitive Tools and Standard Neuropsychological Tests Used to Assess Sport Concussion: A Systematic Review.Neuropsychology review · 2023Pooled it
- Towards a Multidimensional Model of Neurocognitive Disorders (MOND Model): Integrating Evidence from a Critical Review into a Model for Future Research.Journal of personalized medicine · 2026Review
- Development and validation of an Online Comprehensive Geriatric Screening (O-CGS) Tool.BMC public health · 2026Article
- Evaluating Cognition Across Aging and Traumatic Brain Injury: Integrating Neurological and Neuropsychological Approaches.Journal of clinical medicine · 2026Review
- A Scoping Review of Clinical Utility from the Montreal Cognitive Assessment Memory Index Score.Journal of geriatric psychiatry and neurology · 2026Article
- Low Sensitivity of Neuropsychological Scales Hinder Detection of Potential Benefit of Treatments in Alzheimer's Disease: A Position Paper.European journal of neurology · 2026Review
- Linking eye movements, pupil responses, and brain networks in early cognitive decline.Alzheimer's research & therapy · 2026Article
- The contribution of verbal delayed recall to phonemic but not semantic fluency in aging individuals.Oxford open neuroscience · 2026Article
- Montreal Cognitive Assessment (MoCA) Scale: Strengths, Limitations, and Implication for Clinical Practice.Iranian journal of psychiatry · 2026Review
- Scalable biological-cognitive profiling for Alzheimer's disease in the population.Brain communications · 2026Article
- A Scoping Review on Conversational Memory and Characteristics of Conversations in Alzheimer's Disease.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Validity of the Loewenstein-Acevedo Scales of Semantic Interference and Learning (LASSI-L) for Mexican Subjects with Mild and Moderate Cognitive Impairments.Geriatrics (Basel, Switzerland) · 2025Article
- Are pNF-H, IL-6, BDNF, and NSP Reliable Biomarkers of Cognitive Function in Prostate Cancer Patients?International journal of molecular sciences · 2025Article
- Amyloid PET and clinical management in a diverse, cognitively impaired population: The New IDEAS Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Effects of Persistent Depression on Recall Memory are Moderated by Subjective Age Levels: Evidence From Community-Dwelling Older Adults.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Predictive value of an unsupervised web-based assessment of the neuropsychological function.Scientific reports · 2025Article
- Article
- Clinical variables contributing to the identification of biologically defined subgroups within cognitively unimpaired and mild cognitive impairment individuals.European journal of neurology · 2024Article
- Evidence for the role of affective theory of mind in face-name associative memory.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
With an increasing focus on biomarkers in dementia research, illustrating the role of neuropsychological assessment in detecting mild cognitive impairment (MCI) and Alzheimer's dementia (AD) is important. This systematic review and meta-analysis, conducted in accordance with PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) standards, summarizes the sensitivity and specificity of memory measures in individuals with MCI and AD. Both meta-analytic and qualitative examination of AD versus healthy control (HC) studies (n = 47) revealed generally high sensitivity and specificity (≥ 80% for AD comparisons) for measures of immediate (sensitivity = 87%, specificity = 88%) and delayed memory (sensitivity = 89%, specificity = 89%), especially those involving word-list recall. Examination of MCI versus HC studies (n = 38) revealed generally lower diagnostic accuracy for both immediate (sensitivity = 72%, specificity = 81%) and delayed memory (sensitivity = 75%, specificity = 81%). Measures that differentiated AD from other conditions (n = 10 studies) yielded mixed results, with generally high sensitivity in the context of low or variable specificity. Results confirm that memory measures have high diagnostic accuracy for identification of AD, are promising but require further refinement for identification of MCI, and provide support for ongoing investigation of neuropsychological assessment as a cognitive biomarker of preclinical AD. Emphasizing diagnostic test accuracy statistics over null hypothesis testing in future studies will promote the ongoing use of neuropsychological tests as Alzheimer's disease research and clinical criteria increasingly rely upon cerebrospinal fluid (CSF) and neuroimaging biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.