ArticleAnnals of biomedical engineering2017
Are DXA/aBMD and QCT/FEA Stiffness and Strength Estimates Sensitive to Sex and Age?
Article in Annals of biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Computational Assessment of Fracture Risk in Vertebral Bodies With Simulated Defects: The Role of Baseline Strength and Tumor Size.International journal for numerical methods in biomedical engineering · 2025Article
- Exploring Causality Between Bone Mineral Density and Cervical Spondylosis: Bidirectional and Multivariable Mendelian Randomization Study.Journal of pain research · 2025Article
- Utilizing radiomics techniques to isolate a single vertebral body from chest CT for opportunistic osteoporosis screening.BMC musculoskeletal disorders · 2024Article
- Associations between body composition, physical activity, and diet and radial bone microarchitecture in older adults: a 10-year population-based study.Archives of osteoporosis · 2022Article
- Influence of aging on mechanical properties of the femoral neck using an inverse method.Bone reports · 2022Article
- Single-level subject-specific finite element model can predict fracture outcomes in three-level spine segments under different loading rates.Computers in biology and medicine · 2021Article
- Mechanical metric for skeletal biomechanics derived from spectral analysis of stiffness matrix.Scientific reports · 2021Article
- Imaging Modalities to Assess Fracture Healing.Current osteoporosis reports · 2020Review
- Triglyceride Can Predict the Discordance between QCT and DXA Screening for BMD in Old Female Patients.Disease markers · 2020Article
- Optimizing Accuracy of Proximal Femur Elastic Modulus Equations.Annals of biomedical engineering · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
Dual X-ray absorptiometry (DXA) measures areal bone mineral density (aBMD) by simplifying a complex 3D bone structure to a 2D projection and is not equally effective for explaining fracture strength in women and men. Unlike DXA, subject-specific quantitative computed tomography-based finite element analysis (QCT/FEA) estimates fracture strength using 3D bone mineral distribution and geometry. By using experimentally-measured femoral stiffness and strength from a one hundred sample cadaveric cohort that included variations in sex and age, we wanted to determine if QCT/FEA estimates were able to better predict the experimental variations than DXA/aBMD. For each femur, DXA/aBMD was assessed and a QCT/FEA model was developed to estimate femoral stiffness and strength. Then, the femur was mechanically tested to fracture in a sideways fall on the hip position to measure stiffness and strength. DXA/aBMD and QCT/FEA estimates were compared for their sensitivity to sex and age with multivariate statistical analyses. When comparing the measured data with DXA/aBMD predictions, both age and sex were significant (p ≤ 0.0398) for both femoral stiffness and strength. However, QCT/FEA predictions of stiffness and strength showed sex was insignificant (p ≥ 0.23). Age was still significant (p ≤ 0.0072). These results indicate that QCT/FEA, unlike DXA/aBMD, accounted for bone differences due to sex.
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