ArticlePediatric nephrology (Berlin, Germany)2018
Accumulation of uraemic toxins is reflected only partially by estimated GFR in paediatric patients with chronic kidney disease.
Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Pooled it
- Trial
- The Non-Traditional Cardiovascular Culprits in Chronic Kidney Disease: Mineral Imbalance and Uremic Toxin Accumulation.International journal of molecular sciences · 2025Review
- Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence.Amino acids · 2023Article
- CARPEDIEM® for continuous kidney replacement therapy in neonates and small infants: a French multicenter retrospective study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Low-molecular weight inhibitors of the alternative complement pathway.Immunological reviews · 2023Review
- Asymmetric and Symmetric Dimethylarginines as Renal Function Parameters in Paediatric Kidney Diseases: A Literature Review from 2003 to 2022.Children (Basel, Switzerland) · 2022Review
- Dimethylarginines in Children after Anti-Neoplastic Treatment.Medicina (Kaunas, Lithuania) · 2022Article
- Review
- Serum Myo-Inositol, Dimethyl Sulfone, and Valine in Combination with Creatinine Allow Accurate Assessment of Renal Insufficiency-A Proof of Concept.Diagnostics (Basel, Switzerland) · 2021Article
- Article
- Uremic Toxin Concentrations are Related to Residual Kidney Function in the Pediatric Hemodialysis Population.Toxins · 2019Article
- Measuring serum total and free indoxyl sulfate and p-cresyl sulfate in chronic kidney disease using UPLC-MS/MS.Journal of food and drug analysis · 2019Article
- Chronic Kidney Disease and Dietary Measures to Improve Outcomes.Pediatric clinics of North America · 2019Review
- Evolution of protein-bound uremic toxins indoxyl sulphate and p-cresyl sulphate in acute kidney injury.International urology and nephrology · 2019Article
- Indoxyl Sulphate is Associated with Atrial Fibrillation Recurrence after Catheter Ablation.Scientific reports · 2018Observational
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundChronic kidney disease (CKD) in childhood is characterised by the accumulation of uraemic toxins resulting in a multisystem disorder that has a negative impact on quality of life. Childhood CKD is predominantly defined by a decrease in glomerular filtration rate, estimated (eGFR) by a single serum measurement of endogenous biomarkers, e.g. creatinine. The objective of this study was to evaluate how accurately eGFR predicts the concentration of uraemic toxins in a paediatric CKD cohort.
methodsIn 65 children (10.8 [5.1; 14.7] years) with CKD (eGFR 44 [20; 64] mL/min/1.73 m
resultsUpdated Schwartz eGFR was correlated reasonably well with concentrations of creatinine (r = -0.98), urea (r
conclusionsThis study demonstrates that eGFR poorly predicts concentrations of protein-bound uraemic toxins, UA and ADMA in childhood CKD. Therefore, eGFR only partially reflects the complexity of the accumulation pattern of uraemic toxins in childhood CKD.
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Registered trials
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