Evidence map›Paper›PMID 28939921›Full record

ReviewPediatric nephrology (Berlin, Germany)2019

Pathophysiology and treatment of cardiovascular disease in pediatric chronic kidney disease.

Nadine Khouzam, Katherine Wesseling-Perry

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  5. Review
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  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nadine KhouzamChildren's Hospital Los Angeles, Los Angeles, CA, USA.
Katherine Wesseling-PerryDavid Geffen School of Medicine at UCLA, A2-383 MDCC, 650 Charles Young Drive East, Los Angeles, CA, 90095, USA. kwesseling@mednet.ucla.edu.
Children's Hospital of Los Angeles · US

Funding

NIH HHS DK 80984
6 · The paper itself

Abstract

Life expectancy in patients with all stages of chronic kidney disease (CKD) falls far short of that in the general population. Cardiovascular disease is the leading cause of mortality in pediatric patients with CKD. In contrast to the intimal atherosclerotic lesions that characterize cardiovascular disease in the general population, vascular endothelial dysfunction, medial arterial calcification, and cardiac dysfunction contribute to cardiovascular pathological conditions in CKD. The pathogenesis of these lesions, the origins of which can be identified in the absence of traditional cardiovascular risk factors, is incompletely understood. CKD-mediated vascular calcification in CKD is characterized by a transition of vascular smooth muscle cells to an osteoblast-like phenotype and altered bone and mineral metabolism are strongly linked to progressive cardiovascular disease in this population. Renal osteodystrophy therapies, including phosphate binders, vitamin D analogs, and calcimimetics, have an impact on the progression of cardiovascular disease. However, cardiovascular disease has its origins before the development of secondary hyperparathyroidism, and optimal therapeutic regimens that minimize cardiac dysfunction, vascular calcification, and early mortality remain to be defined.

Indexed as

Age FactorsArteriesBone and BonesCalcimimetic AgentsCardiovascular AgentsCardiovascular DiseasesChelating AgentsChildChronic Kidney Disease-Mineral and Bone DisorderDisease ProgressionEndothelium, VascularHumansKidney TransplantationMineralsRenal Insufficiency, ChronicTunica MediaCalcimimetic AgentsCardiovascular AgentsChelating AgentsMineralsVitamin DCardiac dysfunctionCardiovascular diseaseChronic kidney diseasePediatricsVascular calcificationVascular dysfunction

Identifiers

PMID28939921
OpenAlexW2757629288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.