ArticleScientific reports2017
Determination of extracellular matrix collagen fibril architectures and pathological remodeling by polarization dependent second harmonic microscopy.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Eicosatetraynoic Acid Regulates Profibrotic Pathways in an Induced Pluripotent Stem Cell-Derived Macrophage-Human Intestinal Organoid Model of Crohn's Disease.Journal of Crohn's & colitis · 2025Article
- Spatial polarimetric second harmonic generation evaluation of collagen in a hypophosphatasia mouse model.Biomedical optics express · 2024Article
- Effects of mineralization on the hierarchical organization of collagen-a synchrotron X-ray scattering and polarized second harmonic generation study.Interface focus · 2024Article
- Article
- Quantification of collagen fiber properties in alcoholic liver fibrosis using polarization-resolved second harmonic generation microscopy.Scientific reports · 2023Article
- High numerical aperture imaging allows chirality measurement in individual collagen fibrils using polarization second harmonic generation microscopy.Nanophotonics (Berlin, Germany) · 2023Article
- Inhibition of Collagenase Q1 ofAdvanced therapeutics · 2022Article
- Multiscale modelling of the extracellular matrix.Matrix biology plus · 2022Article
- Exploring the Cell Stemness and the Complexity of the Adipose Tissue Niche.Biomolecules · 2021Article
- Quantitative structural imaging of keratoconic corneas using polarization-resolved SHG microscopy.Biomedical optics express · 2021Article
- Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and Development.Advanced biology · 2021Review
- Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition.Disease models & mechanisms · 2021Article
- Tuning the Structure of Nylon 6,6 Electrospun Bundles to Mimic the Mechanical Performance of Tendon Fascicles.Frontiers in bioengineering and biotechnology · 2021Article
- Intratumoral heterogeneity of second-harmonic generation scattering from tumor collagen and its effects on metastatic risk prediction.BMC cancer · 2020Article
- Biological and bioinspired materials: Structure leading to functional and mechanical performance.Bioactive materials · 2020Article
- X-ray diffraction and second harmonic imaging reveal new insights into structural alterations caused by pressure-overload in murine hearts.Scientific reports · 2020Article
- Maturation of the Meniscal Collagen Structure Revealed by Polarization-Resolved and Directional Second Harmonic Generation Microscopy.Scientific reports · 2019Article
- Whole-Section Tumor Micro-Architecture Analysis by a Two-Dimensional Phasor-Based Approach Applied to Polarization-Dependent Second Harmonic Imaging.Frontiers in oncology · 2019Article
- Polarization-resolved second harmonic microscopy of skeletal muscle in sepsis.Biomedical optics express · 2018Article
- μMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polarization dependence second harmonic generation (P-SHG) microscopy is gaining increase popularity for in situ quantification of fibrillar protein architectures. In this report, we combine P-SHG microscopy, new linear least square (LLS) fitting and modeling to determine and convert the complex second-order non-linear optical anisotropy parameter ρ of several collagen rich tissues into a simple geometric organization of collagen fibrils. Modeling integrates a priori knowledge of polyhelical organization of collagen molecule polymers forming fibrils and bundles of fibrils as well as Poisson photonic shot noise of the detection system. The results, which accurately predict the known sub-microscopic hierarchical organization of collagen fibrils in several tissues, suggest that they can be subdivided into three classes according to their microscopic and macroscopic hierarchical organization of collagen fibrils. They also show, for the first time to our knowledge, intrahepatic spatial discrimination between genuine fibrotic and non-fibrotic vessels. CCl
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.