Evidence map›Paper›PMID 28939894›Full record

ArticleScientific reports2017

Plasticity of Human Meniscus Fibrochondrocytes: A Study on Effects of Mitotic Divisions and Oxygen Tension.

Yan Liang, Enaam Idrees, Stephen H J Andrews, Kirollos Labib, Alexander Szojka, Melanie Kunze, Andrea D Burbank, Aillette Mulet-Sierra, Nadr M Jomha, Adetola B Adesida

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. The clinical potential of meniscal progenitor cells.The journal of cartilage & joint preservation · 2024
    Review
  4. Article
  5. Allografts for partial meniscus repair: anFrontiers in bioengineering and biotechnology · 2023
    Article
  6. Article
  7. Article
  8. Engineered Human Meniscus in Modeling Sex Differences of Knee OsteoarthritisFrontiers in bioengineering and biotechnology · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Mechano-Hypoxia Conditioning of Engineered Human Meniscus.Frontiers in bioengineering and biotechnology · 2021
    Article
  16. Article
  17. Adult ovine chondrocytes in expansion culture adopt progenitor cell properties that are favorable for cartilage tissue engineering.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Yan LiangUniversity of Alberta, Department of Surgery, Divisions of Orthopaedic Surgery and Surgical Research, Edmonton, T6G 2E1, Canada.
Enaam IdreesUniversity of Alberta, Department of Surgery, Divisions of Orthopaedic Surgery and Surgical Research, Edmonton, T6G 2E1, Canada.
Stephen H J AndrewsUniversity of Alberta, Department of Surgery, Divisions of Orthopaedic Surgery and Surgical Research, Edmonton, T6G 2E1, Canada.ORCID 0000-0002-3851-2197
Kirollos LabibUniversity of Alberta, Department of Surgery, Divisions of Orthopaedic Surgery and Surgical Research, Edmonton, T6G 2E1, Canada.
Alexander SzojkaUniversity of Alberta, Department of Surgery, Divisions of Orthopaedic Surgery and Surgical Research, Edmonton, T6G 2E1, Canada.
Melanie KunzeUniversity of Alberta, Department of Surgery, Divisions of Orthopaedic Surgery and Surgical Research, Edmonton, T6G 2E1, Canada.
Andrea D BurbankUniversity of Alberta, Department of Surgery, Divisions of Orthopaedic Surgery and Surgical Research, Edmonton, T6G 2E1, Canada.ORCID 0000-0002-7425-8616
Aillette Mulet-SierraUniversity of Alberta, Department of Surgery, Divisions of Orthopaedic Surgery and Surgical Research, Edmonton, T6G 2E1, Canada.
Nadr M JomhaUniversity of Alberta, Department of Surgery, Divisions of Orthopaedic Surgery and Surgical Research, Edmonton, T6G 2E1, Canada.
Adetola B AdesidaUniversity of Alberta, Department of Surgery, Divisions of Orthopaedic Surgery and Surgical Research, Edmonton, T6G 2E1, Canada. adesida@ualberta.ca.ORCID 0000-0003-1798-6251
University of Alberta · CA

Funding

CIHR 125921-1
6 · The paper itself

Abstract

Meniscus fibrochondrocytes (MFCs) may be the optimal cell source to repair non-healing meniscus injuries using tissue engineering strategies. In this study, we investigated the effects of mitotic divisions and oxygen tension on the plasticity of adult human MFCs. Our assessment techniques included gene expression, biochemical, histological, and immunofluorescence assays. MFCs were expanded in monolayer culture with combined growth factors TGFβ1 and FGF-2 (T1F2) under normoxia (21% O

Indexed as

Cell DifferentiationCell ProliferationAdipogenesisAdultCell HypoxiaCells, CulturedChondrocytesFibroblast Growth Factor 2HumansMeniscusMitosisOsteogenesisOxygenTissue EngineeringTransforming Growth Factor beta1Young AdultFibroblast Growth Factor 2OxygenTransforming Growth Factor beta1

Identifiers

PMID28939894
PMCPMC5610182
OpenAlexW2754591136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.