Evidence map›Paper›PMID 28939876›Full record

ArticleScientific reports2017

Thrombopoietic stimulating activity of rhTyrRS (Y341A).

Yu Jinchao, Zhang Yanling, Wang Xu, Zhao Bing, Ye Yuhao, Zhou Weiran, Sun Shaoyang, Ma Liyun, Shi Yun, Zhan Ling and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yu JinchaoThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Zhang YanlingThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Wang XuThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Zhao BingThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Ye YuhaoThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Zhou WeiranThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Sun ShaoyangThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Ma LiyunThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Shi YunThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Zhan LingThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Yu MinThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China.
Mo WeiThe Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 238# P.O. Box, 138 Yixueyan Rd., Shanghai, 200032, Shanghai Shi, China. weimo1025@shmu.edu.cn.
Shanghai Medical College of Fudan University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor radiotherapy induces hematopoietic organ damage and reduces thrombocyte counts. Thrombocytopenia is a common disease. Some studies have shown that tRNA synthetase plays not only catalytic tRNA aminoacylation roles, but also functions similarly to cytokines. Recombinant human tyrosyl-tRNA synthetase with a mutated Y341A (rhTyrRS (Y341A)) promotes megakaryocyte migrate from bone marrow to peripheral blood. It would promote megakaryocytes in the lungs adhering to vascular endothelial cells and resulting in the platelet production. The purpose of this research was to investigate the efficacy of rhTyrRS (Y341A) as a therapy for thrombocytopenia and to explore its mechanism of action. We found platelet number was effectively increased by rhTyrRS (Y341A) via platelet count and reticulated platelets (RPs) flow cytometry. We also demonstrated radiation-induced thrombocytopenia could be prevented by rhTyrRS (Y341A). The results of immunohistochemistry and H&E staining showed the number of pulmonary mature megakaryocytes was significantly increased in rhTyrRS (Y341A) treated groups. In transgenic zebrafish larvae, confocal microscopy results showed rhTyrRS (Y341A) promoted the migration and adhesion of megakaryocytes. These results suggested that rhTyrRS (Y341A) promote megakaryocytes in bone marrow migrating to lungs through blood circulation. rhTyrRS (Y341A) may be an effective medicine which could be used to treat patients suffering from thrombocytopenia.

Indexed as

AnimalsAnimals, Genetically ModifiedBlood PlateletsCell MovementDisease Models, AnimalFemaleHumansHuman Umbilical Vein Endothelial CellsMaleMegakaryocytesMiceMice, Inbred C57BLMutationNeoplasmsPlatelet CountRadiotherapyRecombinant ProteinsTyrosine-tRNA Ligase

Identifiers

PMID28939876
PMCPMC5610193
OpenAlexW2754568792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.