ArticleNature communications2017
Cortical Up states induce the selective weakening of subthreshold synaptic inputs.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Detailed study of bifurcations in a rate model with excitatory and inhibitory neurons and adaptation.Journal of computational neuroscience · 2026Article
- Induction of cortical on/off periods in awake mice fulfills sleep functions.Nature neuroscience · 2026Article
- A hippocampal 'sharp-wave sleep' state that is dissociable from cortical sleep.Nature neuroscience · 2026Article
- Vigilance state dissociation induced by 5-MeO-DMT in mice.Communications biology · 2026Article
- Brain-wide properties of slow waves across vigilance states.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Preconfigured neuronal firing sequences in human brain organoids.Nature neuroscience · 2026Article
- Abnormal local markers of sleep homeostasis in patients with focal epilepsy.Brain communications · 2026Article
- Direct intracranial EEG evidence for a local breakdown in normal sleep homeostasis at the human seizure onset zone.medRxiv : the preprint server for health sciences · 2025Article
- Induction of cortical ON/OFF periods in awake mice fulfills sleep functions.bioRxiv : the preprint server for biology · 2025Article
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- Effects of non-rapid eye movement sleep on the cortical synaptic expression of GluA1-containing AMPA receptors.The European journal of neuroscience · 2024Article
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- Creation of Neuronal Ensembles and Cell-Specific Homeostatic Plasticity through Chronic Sparse Optogenetic Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Information maximization explains state-dependent synaptic plasticity and memory reorganization during non-rapid eye movement sleep.PNAS nexus · 2023Article
- Neuronal-spiking-based closed-loop stimulation during cortical ON- and OFF-states in freely moving mice.Journal of sleep research · 2022Article
- The hypothalamic link between arousal and sleep homeostasis in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Differential Excitability of PV and SST Neurons Results in Distinct Functional Roles in Inhibition Stabilization of Up States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cell-Type-Specific Dynamics of Calcium Activity in Cortical Circuits over the Course of Slow-Wave Sleep and Rapid Eye Movement Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Decreased reproducibility and abnormal experience-dependent plasticity of network dynamics in Fragile X circuits.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Slow-wave sleep is thought to be important for retuning cortical synapses, but the cellular mechanisms remain unresolved. During slow-wave activity, cortical neurons display synchronized transitions between depolarized Up states and hyperpolarized Down states. Here, using recordings from LIII pyramidal neurons from acute slices of mouse medial entorhinal cortex, we find that subthreshold inputs arriving during the Up state undergo synaptic weakening. This does not reflect a process of global synaptic downscaling, as it is dependent on presynaptic spiking, with network state encoded in the synaptically evoked spine Ca
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