ArticleScientific reports2017
Sensing bacterial vibrations and early response to antibiotics with phase noise of a resonant crystal.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
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- A rapid method of evaluating cytotoxic drug efficacy using sub-cellular fluctuation imaging.Scientific reports · 2025Article
- Unraveling Bacterial Single-Stranded Sequence Specificities: Insights from Molecular Dynamics and MMPBSA Analysis of Oligonucleotide Probes.Molecular biotechnology · 2024Review
- Sensor system for analysis of biofilm sensitivity to ampicillin.Applied microbiology and biotechnology · 2024Article
- Accurate Prediction of Antimicrobial Susceptibility for Point-of-Care Testing of Urine in Less than 90 Minutes via iPRISM Cassettes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Electroacoustic Biosensor Systems for Evaluating Antibiotic Action on Microbial Cells.Sensors (Basel, Switzerland) · 2023Review
- The Hypothesis of a "Living Pulse" in Cells.Life (Basel, Switzerland) · 2023Article
- Use ofADMET & DMPK · 2023Article
- Differences in bacteria nanomotion profiles and neutrophil nanomotion during phagocytosis.Frontiers in microbiology · 2023Article
- Microbial Acoustical Analyzer for Antibiotic Indication.Sensors (Basel, Switzerland) · 2022Article
- Preparation, Characterization, andInternational journal of nanomedicine · 2022Article
- Single yeast cell nanomotions correlate with cellular activity.Science advances · 2020Article
- Innovative and rapid antimicrobial susceptibility testing systems.Nature reviews. Microbiology · 2020Review
- Detection of Antibiotics and Evaluation of Antibacterial Activity with Screen-Printed Electrodes.Sensors (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The speed of conventional antimicrobial susceptibility testing (AST) is intrinsically limited by observation of cell colony growth, which can extend over days and allow bacterial infections to advance before effective antibiotics are identified. This report presents an approach for rapidly sensing mechanical fluctuations of bacteria and the effects of antibiotics on these fluctuations. Bacteria are adhered to a quartz crystal resonator in an electronic bridge that is driven by a high-stability frequency source. Mechanical fluctuations of cells introduce time-dependent perturbations to the crystal boundary conditions and associated resonant frequency, which translate into phase noise measured at the output of the bridge. In experiments on nonmotile E. coli exposed to polymyxin B, cell-generated frequency noise dropped close to zero with the first spectra acquired 7 minutes after introduction of the antibiotic. In experiments on the same bacterial strain exposed to ampicillin, frequency noise began decreasing within 15 minutes of antibiotic introduction and proceeded to drop more rapidly with the onset of antibiotic-induced lysis. In conjunction with cell imaging and post-experiment counting of colony-forming units, these results provide evidence that cell death can be sensed through measurements of cell-generated frequency noise, potentially providing a basis for rapid AST.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.