ArticleScientific reports2017
Scalable Spatial-Spectral Multiplexing of Single-Virus Detection Using Multimode Interference Waveguides.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Virosome-masked ratiometric nanoprobes for in vivo dynamic imaging of influenza a virus infection.Journal of nanobiotechnology · 2026Article
- Article
- Fluorescent Biosensors for the Detection of Viruses Using Graphene and Two-Dimensional Carbon Nanomaterials.Biosensors · 2022Review
- Fast custom wavelet analysis technique for single molecule detection and identification.Nature communications · 2022Article
- Free-Space Excitation of Optofluidic Devices for Pattern-Based Single Particle Detection.IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society · 2021Article
- Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip.APL photonics · 2021Article
- Optofluidic multiplex detection of single SARS-CoV-2 and influenza A antigens using a novel bright fluorescent probe assay.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- On-Chip Optical Detection of Viruses: A Review.Advanced photonics research · 2021Article
- 7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening.Optics express · 2020Article
- 3× multiplexed detection of antibiotic resistant plasmids with single molecule sensitivity.Lab on a chip · 2020Article
- Integration of sample preparation and analysis into an optofluidic chip for multi-target disease detection.Lab on a chip · 2018Article
- Buried Rib SiOIEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society · 2018Article
- Multi-channel velocity multiplexing of single virus detection on an optofluidic chip.Optics letters · 2018Article
- Optofluidic detection of Zika nucleic acid and protein biomarkers using multimode interference multiplexing.Biomedical optics express · 2018Article
- Optimized ARROW-Based MMI Waveguides for High Fidelity Excitation Patterns for Optofluidic Multiplexing.IEEE journal of quantum electronics · 2018Article
- Optofluidic Amplification-free Multiplex Detection of Viral Hemorrhagic Fevers.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
- Enhanced Detection of Single Viruses On-Chip via Hydrodynamic Focusing.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
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7 authors.
Funding
Abstract
Simultaneous detection of multiple pathogens and samples (multiplexing) is one of the key requirements for diagnostic tests in order to enable fast, accurate and differentiated diagnoses. Here, we introduce a novel, highly scalable, photonic approach to multiplex analysis with single virus sensitivity. A solid-core multimode interference (MMI) waveguide crosses multiple fluidic waveguide channels on an optofluidic chip to create multi-spot excitation patterns that depend on both the wavelength and location of the channel along the length of the MMI waveguide. In this way, joint spectral and spatial multiplexing is implemented that encodes both spatial and spectral information in the time dependent fluorescence signal. We demonstrate this principle by using two excitation wavelengths and three fluidic channels to implement a 6x multiplex assay with single virus sensitivity. High fidelity detection and identification of six different viruses from a standard influenza panel is reported. This multimodal multiplexing strategy scales favorably to large numbers of targets or large numbers of clinical samples. Further, since single particles are detected unbound in flow, the technique can be broadly applied to direct detection of any fluorescent target, including nucleic acids and proteins.
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Registered trials
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