Evidence map›Paper›PMID 28939771›Full record

ArticleThe Journal of biological chemistry2017

Endonucleolytic cleavage in the expansion segment 7 of 25S rRNA is an early marker of low-level oxidative stress in yeast.

Daniel Shedlovskiy, Jessica A Zinskie, Ethan Gardner, Dimitri G Pestov, Natalia Shcherbik

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

  1. eLife · 2026
    Article
  2. Dissecting the small RNA code of inflammatory bowel disease.Molecular medicine (Cambridge, Mass.) · 2026
    Article
  3. The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Ribosome Assembly and Repair.Annual review of cell and developmental biology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daniel ShedlovskiyFrom the Department of Cell Biology and Neuroscience and.
Jessica A ZinskieFrom the Department of Cell Biology and Neuroscience and.
Ethan GardnerFrom the Department of Cell Biology and Neuroscience and.
Dimitri G PestovFrom the Department of Cell Biology and Neuroscience and.
Natalia ShcherbikFrom the Department of Cell Biology and Neuroscience and shcherna@rowan.edu.
Rowan University · US

Funding

Translational Rescue Mechanisms in EukaryotesR01GM114308 · NIGMS · ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED · PI SHCHERBIK, NATALIA · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM114308
6 · The paper itself

Abstract

The ability to detect and respond to oxidative stress is crucial to the survival of living organisms. In cells, sensing of increased levels of reactive oxygen species (ROS) activates many defensive mechanisms that limit or repair damage to cell components. The ROS-signaling responses necessary for cell survival under oxidative stress conditions remain incompletely understood, especially for the translational machinery. Here, we found that drug treatments or a genetic deficiency in the thioredoxin system that increase levels of endogenous hydrogen peroxide in the yeast

Indexed as

Gene Expression Regulation, FungalOxidative StressApoptosisBiomarkersGene DeletionHormesisKineticsNucleic Acid ConformationOxidantsPeroxidasesPolyribosomesReactive Oxygen SpeciesReducing AgentsRNA CleavageRNA, FungalRNA, RibosomalBiomarkersOxidantsPeroxidasesReactive Oxygen SpeciesReducing AgentsRNA, FungalRNA, RibosomalRNA, ribosomal, 25SSaccharomyces cerevisiae ProteinsTsa1 protein, S cerevisiaeoxidation-reduction (redox)oxidative stressreactive oxygen species (ROS)redox signalingribosomal ribonucleic acid (rRNA) (ribosomal RNA)ribosomeRNA degradationRNA structureSaccharomyces cerevisiaestress response

Identifiers

PMID28939771
PMCPMC5682959
OpenAlexW2759027933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.