Evidence map›Paper›PMID 28939757›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8

Arash Memarnejadian, Courtney E Meilleur, Christopher R Shaler, Khashayarsha Khazaie, Jack R Bennink, Todd D Schell, S M Mansour Haeryfar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Anti-PD-1 and anti-PD-L1 antibodies for glioma.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. T cell help in the autoreactive germinal center.Scandinavian journal of immunology · 2022
    Review
  15. Review
  16. Neoadjuvant Therapy for Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2022
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arash MemarnejadianDepartment of Microbiology and Immunology, Western University, London, Ontario N6A 5C1, Canada.
Courtney E MeilleurDepartment of Microbiology and Immunology, Western University, London, Ontario N6A 5C1, Canada.
Christopher R ShalerDepartment of Microbiology and Immunology, Western University, London, Ontario N6A 5C1, Canada.
Khashayarsha KhazaieDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905.
Jack R BenninkLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Todd D SchellDepartment of Microbiology and Immunology, Pennsylvania State University, Hershey, PA 17033.ORCID 0000-0002-6788-6518
S M Mansour HaeryfarDepartment of Microbiology and Immunology, Western University, London, Ontario N6A 5C1, Canada; Mansour.Haeryfar@schulich.uwo.ca.ORCID 0000-0002-1125-8176

Funding

Virus Induction Of Primary CD8 T Cell ResponsesZIAAI000814 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BENNINK, JACK R · 2009 to 2020
$6.8M
CD8+ T Cell-Mediated Immunotherapy of Autochthonous SV40 T Antigen-Induced TumorsR01CA025000 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SCHELL, TODD D · 1985 to 2014
$5.0M
BIOLOGY OF SV40-SPECIFIC TRANSPLANTATION ANTIGENR37CA025000 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI TEVETHIA, SATVIR S. · 1988 to 2002
$1.7M
CIHR MOP-130465NCI NIH HHS R01 CA025000NCI NIH HHS R37 CA025000
6 · The paper itself

Abstract

The interactions between programmed death-1 (PD-1) and its ligands hamper tumor-specific CD8

Indexed as

Immunity, CellularAnimalsCD8-Positive T-LymphocytesCell DeathCell Line, TumorEpitopesFemaleInterferon-gammaMiceNeoplasm ProteinsNeoplasms, ExperimentalProgrammed Cell Death 1 ReceptorSignal TransductionEpitopesIFNG protein, mouseInterferon-gammaNeoplasm ProteinsPdcd1 protein, mouseProgrammed Cell Death 1 Receptor

Identifiers

PMID28939757
PMCPMC5731479

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.