Evidence map›Paper›PMID 28939710›Full record

ArticleJournal of the American Heart Association2017

Hemodynamic Profile of Patients With Heart Failure and Preserved Ejection Fraction Vary by Age.

Shane Nanayakkara, Mark Haykowsky, Justin Mariani, Vanessa Van Empel, Micha T Maeder, Donna Vizi, David M Kaye

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Shane NanayakkaraDepartment of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
Mark HaykowskyCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX.
Justin MarianiDepartment of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
Vanessa Van EmpelDepartment of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Micha T MaederCardiology Department, Kantonsspital St. Gallen, Switzerland.
Donna ViziDepartment of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
David M KayeDepartment of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia david.kaye@bakeridi.edu.au.
Monash University · AUBaker Heart and Diabetes Institute · AUKantonsspital St. Gallen · CHMaastricht University Medical Centre · NLThe Alfred Hospital · AUThe University of Texas at Arlington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with heart failure with preserved ejection fraction (HFpEF) exhibit a range of cardiovascular phenotypic profiles modified by several common comorbidities. In particular, patients with HFpEF tend to be older; however, it is unclear whether the effects of cardiovascular aging per se modify the expression of HFpEF. We therefore sought to investigate the interaction between age and physiologic profile in patients with HFpEF. METHODS AND

resultsWe assessed the hemodynamic and metabolic profile of 40 patients with HFpEF. Patients underwent right heart catheterization at rest and during supine cycle ergometry, and were segregated into 2 groups by the median age of the cohort. Older patients with HFpEF demonstrated reduced resting cardiac output (4.8±1.2 L/min versus 5.7±1.1 L/min). With exercise, older patients demonstrated a marked rise in arteriovenous oxygen content difference (10.8±1.8 versus 7.9±2.4 mL,

conclusionsOlder patients with HFpEF display a different physiological phenotype compared with younger patients, with enhanced oxygen extraction and lower increment in cardiac output to increase oxygen consumption from rest to peak supine exercise. This finding highlights the importance in considering age when considering therapeutic options in patients with HFpEF.

Indexed as

Stroke VolumeVentricular Function, LeftAgedAge FactorsBiomarkersBlood Gas AnalysisCardiac CatheterizationExercise TestFemaleHeart FailureHumansMaleMiddle AgedOxygenOxygen ConsumptionPhenotypeBiomarkersOxygenaginggeriatricsheart failure with preserved ejection fractionhemodynamicsoxygen extraction

Identifiers

PMID28939710
PMCPMC5634249
OpenAlexW2759324314

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.