ArticleCancer research2017
Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy.
Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Wnt Signaling Across Adult Skin Mini-Organs: Interfollicular Epidermis, Hair Follicle, and Nail-Implications for Disease and Regeneration.International journal of molecular sciences · 2026Review
- Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology.American journal of clinical dermatology · 2026Review
- Pediatric Radiation-Induced Alopecia Post Intracranial Vascular Malformation Embolization: A Case Report with Dermoscopic Findings.Clinical, cosmetic and investigational dermatology · 2026Article
- Recent advances in understanding of radiation-induced skin tissue reactions with respect to acute tissue injury and late adverse effect.Journal of radiation research · 2025Review
- Generation of theInternational journal of molecular sciences · 2025Article
- Evolution of long scalp hair in humans.The British journal of dermatology · 2025Review
- Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis.International journal of molecular sciences · 2024Review
- Modeling of ionizing radiation induced hair follicle regenerative dynamics.Journal of theoretical biology · 2022Article
- Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth.Pflugers Archiv : European journal of physiology · 2022Article
- Regulation and dysregulation of hair regeneration: aiming for clinical application.Cell regeneration (London, England) · 2022Review
- Kartogenin regulates hair growth and hair cycling transition.International journal of medical sciences · 2022Article
- The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages.Biological reviews of the Cambridge Philosophical Society · 2021Article
- High-resolution single-cell transcriptomics reveals heterogeneity of self-renewing hair follicle stem cells.Experimental dermatology · 2021Article
- Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation.Journal of radiation research · 2021Article
- Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss.International journal of molecular sciences · 2020Review
- Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration.Journal of biomedical science · 2020Review
- CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia.EMBO molecular medicine · 2019Article
- Radiation-Induced Skin Fibrosis: Pathogenesis, Current Treatment Options, and Emerging Therapeutics.Annals of plastic surgery · 2019Review
- Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy.Nature communications · 2019Article
- Promotion of homology-directed DNA repair by polyamines.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encountered in cancer treatment, and there is a lack of effective treatment. In growing hair follicles (HF), quiescent stem cells (SC) are maintained in the bulge region, and hair bulbs at the base contain rapidly dividing, yet genotoxicity-sensitive transit-amplifying cells (TAC) that maintain hair growth. How genotoxicity-induced HF injury is repaired remains unclear. We report here that HFs mobilize ectopic progenitors from distinct TAC compartments for regeneration in adaptation to the severity of dystrophy induced by ionizing radiation (IR). Specifically, after low-dose IR, keratin 5
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.