Trial reportStroke2017
Safety Outcomes After Percutaneous Transcatheter Closure of Patent Foramen Ovale.
Trial report in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Outcomes of patent foramen ovale closure in patients over 60 years with cryptogenic stroke: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2026Pooled it
- New-onset atrial fibrillation following percutaneous closure of patent foramen ovale: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Pooled it
- Closure, Anticoagulation, or Antiplatelet Therapy for Cryptogenic Stroke With Patent Foramen Ovale: Systematic Review of Randomized Trials, Sequential Meta-Analysis, and New Insights From the CLOSE Study.Journal of the American Heart Association · 2018Pooled it
- Diagnosis and Management of Patients with Patent Foramen Ovale: Current Evidence and Future Perspective.Journal of cardiovascular development and disease · 2026Review
- Toward a minimalist strategy for PFO closure: outcomes and patient experience from 205 ICE-guided procedures performed under local anesthesia and early discharge.Cardiovascular intervention and therapeutics · 2026Article
- Comparison of safety and short-term outcomes of septostomy and direct tunnel passage techniques in percutaneous patent foramen ovale closure: a multicenter experience.Frontiers in cardiovascular medicine · 2026Article
- Percutaneous Closure of Patent Foramen Ovale in Ischemic Stroke: A Single-Center Experience.Acta Cardiologica Sinica · 2025Article
- A Novel Patent Foramen Ovale Occluder With Left Clamp Arms: Preclinical Experiment and First-in-Human Study.JACC. Basic to translational science · 2025Article
- Uncovering the Risks and Benefits of Patent Foramen Ovale (PFO) Closure in Cryptogenic Stroke: A Case Study.Cureus · 2024Article
- Multidisciplinary Approach to Patent Foramen Ovale Closure for Cryptogenic Stroke: Brain-Heart Board Experience.Neurology. Clinical practice · 2024Article
- Device Closure or Antithrombotic Therapy After Cryptogenic Stroke in Elderly Patients With a High-Risk Patent Foramen Ovale.Journal of stroke · 2024Article
- Atrial Fibrillation After Patent Foramen Ovale Closure: Innocuous Passerby or Propagating Substrate.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Incidence of Atrial Fibrillation or Arrhythmias After Patent Foramen Ovale Closure.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Impact of frailty index on cardiovascular outcomes and readmissions of patent foramen ovale closure procedure: a propensity matched national analysis.American journal of cardiovascular disease · 2024Review
- Approval, Evidence, and "Off-Label" Device Utilization: The Patent Foramen Ovale Closure Story.Circulation. Cardiovascular quality and outcomes · 2024Article
- Patent Foramen Ovale Percutaneous Closure: Evolution and Ongoing Challenges.Journal of clinical medicine · 2023Review
- Patent Foramen Ovale and Cryptogenic Stroke: Integrated Management.Journal of clinical medicine · 2023Review
- Case report: Malignant vasovagal reflex syndrome during percutaneous transcatheter closure of patent foramen ovale.Frontiers in cardiovascular medicine · 2023Article
- Sex differences in baseline profiles and short-term outcomes in patients undergoing closure of patent foramen ovale.American heart journal plus : cardiology research and practice · 2022Article
- Integrated care for optimizing the management of stroke and associated heart disease: a position paper of the European Society of Cardiology Council on Stroke.European heart journal · 2022Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
7 authors.
Funding
Abstract
background and purposeWe sought to evaluate the real-world rate of safety outcomes after patent foramen ovale (PFO) closure in patients with ischemic stroke or transient ischemic attack (TIA).
methodsWe performed a retrospective cohort study using administrative claims data on all hospitalizations from 2005 to 2013 in New York, California, and Florida. Using
resultsWe identified 1887 patients who underwent PFO closure after ischemic stroke or TIA. The rate of any adverse outcome during the hospitalization for PFO closure was 7.0% (95% confidence interval [CI], 5.9%-8.2%). Rates of adverse outcomes varied by age and type of preceding cerebrovascular event. In patients >60 years of age, the rate of adverse outcomes was 10.9% (95% CI, 8.6%-13.6%) versus 4.9% (95% CI, 3.8%-6.3%) in patients ≤60 years of age. The rate of adverse outcomes was 9.9% (95% CI, 7.3%-12.5%) in patients with preceding ischemic stroke versus 5.9% (95% CI, 4.7%-7.1%) after TIA.
conclusionsApproximately 1 in 14 patients who underwent percutaneous transcatheter PFO closure after ischemic stroke or TIA experienced a serious periprocedural adverse outcome or death. The risk of adverse outcomes was highest in older patients and in those with preceding ischemic stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.