ArticleNeurology2017
Mixed neuropathologies and associations with domain-specific cognitive decline.
Abstract read
In one paragraph
Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- The relationship between urinalysis abnormalities, soiling behavior, and cognitive decline in aging dogs.Journal of veterinary internal medicine · 2026Article
- Effects of concurrent neuropathologies with Alzheimer disease neuropathologic change on cognitive decline: Minimal impact of vascular brain injury compared with other combinations.Journal of neuropathology and experimental neurology · 2026Article
- Deep learning-based MRI analysis reveals Lewy body co-pathology accelerates brain aging in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Micro infarcts are associated with cognitive impairment in neurofibrillary tangle predominant decedents: evidence from the NACC autopsy cohort.Alzheimer's research & therapy · 2025Article
- Association of Plasma Placental Growth Factor with White Matter Hyperintensities in Alzheimer's Disease.Biomolecules · 2025Article
- Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co-pathologies, and sex differences.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- The effect of Lewy body (co-)pathology on the clinical and imaging phenotype of amnestic patients.Brain : a journal of neurology · 2025Article
- Non-amnestic initial symptoms may be less prevalent in African American than White participants with Alzheimer's and mixed Lewy body and Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Age-dependent interactions of APOE isoform 4 and Alzheimer's disease neuropathology: findings from the NACC.Acta neuropathologica communications · 2025Article
- The impact of arteriolosclerosis on cognitive impairment in decedents without severe dementia from the National Alzheimer's Coordinating Center.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Correlation between Neuroimaging Scores and Carotid Artery Ultrasound Features in Cerebral Small Vessel Disease Patients.Cerebrovascular diseases extra · 2025Article
- Article
- The Bayesian approach for real-world implementation of plasma p-tau217 in tertiary care memory clinics in Thailand.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Alzheimer Disease Cerebrospinal Fluid Biomarkers in a Tertiary Neurology Practice.Mayo Clinic proceedings · 2024Article
- A cross-sectional study of α-synuclein seed amplification assay in Alzheimer's disease neuroimaging initiative: Prevalence and associations with Alzheimer's disease biomarkers and cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Multiple biomarkers improve diagnostic accuracy across Lewy body and Alzheimer's disease spectra.Annals of clinical and translational neurology · 2024Article
- Lewy body pathology modifies risk factors for cerebral amyloid angiopathy when comorbid with Alzheimer's disease pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Impact of incidental synucleinopathy in mild cognitive impairment due to Alzheimer disease.Journal of neuropathology and experimental neurology · 2024Article
- Characteristics of amnestic patients with hypometabolism patterns suggestive of Lewy body pathology.Brain : a journal of neurology · 2023Article
- Cognitive effects of Lewy body pathology in clinically unimpaired individuals.Nature medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Willa D BrenowitzFrom the National Alzheimer's Coordinating Center (W.D.B., W.T.L., W.A.K.), Department of Pathology (C.D.K.), Department of Epidemiology (S.E.H., W.D.B., W.T.L., W.A.K.), and Department of Neurology (W.T.L.), University of Washington, Seattle; Department of Biostatistics, Epidemiology and Informatics (R.A.H.), University of Pennsylvania, Philadelphia; and Department of Pathology (R.L.W.), Oregon Health & Science University, Portland. W.D.B. is currently with the Department of Epidemiology and Biostatistics, University of California, San Francisco. wbrenow@u.washington.edu.
Rebecca A HubbardFrom the National Alzheimer's Coordinating Center (W.D.B., W.T.L., W.A.K.), Department of Pathology (C.D.K.), Department of Epidemiology (S.E.H., W.D.B., W.T.L., W.A.K.), and Department of Neurology (W.T.L.), University of Washington, Seattle; Department of Biostatistics, Epidemiology and Informatics (R.A.H.), University of Pennsylvania, Philadelphia; and Department of Pathology (R.L.W.), Oregon Health & Science University, Portland. W.D.B. is currently with the Department of Epidemiology and Biostatistics, University of California, San Francisco.
C Dirk KeeneFrom the National Alzheimer's Coordinating Center (W.D.B., W.T.L., W.A.K.), Department of Pathology (C.D.K.), Department of Epidemiology (S.E.H., W.D.B., W.T.L., W.A.K.), and Department of Neurology (W.T.L.), University of Washington, Seattle; Department of Biostatistics, Epidemiology and Informatics (R.A.H.), University of Pennsylvania, Philadelphia; and Department of Pathology (R.L.W.), Oregon Health & Science University, Portland. W.D.B. is currently with the Department of Epidemiology and Biostatistics, University of California, San Francisco.
Stephen E HawesFrom the National Alzheimer's Coordinating Center (W.D.B., W.T.L., W.A.K.), Department of Pathology (C.D.K.), Department of Epidemiology (S.E.H., W.D.B., W.T.L., W.A.K.), and Department of Neurology (W.T.L.), University of Washington, Seattle; Department of Biostatistics, Epidemiology and Informatics (R.A.H.), University of Pennsylvania, Philadelphia; and Department of Pathology (R.L.W.), Oregon Health & Science University, Portland. W.D.B. is currently with the Department of Epidemiology and Biostatistics, University of California, San Francisco.
W T LongstrethFrom the National Alzheimer's Coordinating Center (W.D.B., W.T.L., W.A.K.), Department of Pathology (C.D.K.), Department of Epidemiology (S.E.H., W.D.B., W.T.L., W.A.K.), and Department of Neurology (W.T.L.), University of Washington, Seattle; Department of Biostatistics, Epidemiology and Informatics (R.A.H.), University of Pennsylvania, Philadelphia; and Department of Pathology (R.L.W.), Oregon Health & Science University, Portland. W.D.B. is currently with the Department of Epidemiology and Biostatistics, University of California, San Francisco.
Randy L WoltjerFrom the National Alzheimer's Coordinating Center (W.D.B., W.T.L., W.A.K.), Department of Pathology (C.D.K.), Department of Epidemiology (S.E.H., W.D.B., W.T.L., W.A.K.), and Department of Neurology (W.T.L.), University of Washington, Seattle; Department of Biostatistics, Epidemiology and Informatics (R.A.H.), University of Pennsylvania, Philadelphia; and Department of Pathology (R.L.W.), Oregon Health & Science University, Portland. W.D.B. is currently with the Department of Epidemiology and Biostatistics, University of California, San Francisco.
Walter A KukullFrom the National Alzheimer's Coordinating Center (W.D.B., W.T.L., W.A.K.), Department of Pathology (C.D.K.), Department of Epidemiology (S.E.H., W.D.B., W.T.L., W.A.K.), and Department of Neurology (W.T.L.), University of Washington, Seattle; Department of Biostatistics, Epidemiology and Informatics (R.A.H.), University of Pennsylvania, Philadelphia; and Department of Pathology (R.L.W.), Oregon Health & Science University, Portland. W.D.B. is currently with the Department of Epidemiology and Biostatistics, University of California, San Francisco.
Funding
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MOREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1MTHERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2MVIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1MSatellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3MTREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0MTHE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1MVASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0MVESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GROSSMAN, HILLEL · 1985 to 2019
$37.9M'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MNCRR NIH HHS M01 RR000334NCRR NIH HHS UL1 RR024140NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG053760NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS P50 AG047266NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG024059NIA NIH HHS U01 AG016976
Abstract
objectiveTo test whether decline in specific cognitive domains associated with Alzheimer disease neuropathologic change (ADNC) is modified by co-occurrence of other neuropathologies such as Lewy body disease (LBD) or vascular brain injury (VBI).
methodsData came from 1,603 autopsied participants evaluated at US Alzheimer's Disease Centers. Standardized
resultsCompared to other participants, those with ADNC + LBD generally had worse cognitive trajectories, particularly lower initial executive function and faster attention decline. Participants with ADNC + VBI typically had less impairment and slower decline. Interactions were significant between LBD and ADNC for memory (
conclusionsADNC + LBD (but not ADNC + VBI) was associated with poorer executive function and attention compared to other pathology groupings. However, the effect of co-occurring pathologies on cognitive trajectories may depend on the severity of ADNC. Future studies using antemortem biomarkers should seek to replicate these neuropathologic observations.
Indexed as
AgedAged, 80 and overAlzheimer DiseaseAttentionAutopsyBrainCognition DisordersExecutive FunctionFemaleHumansLanguageLewy Body DiseaseLongitudinal StudiesMaleMemoryNeuropsychological Tests
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.