Evidence map›Paper›PMID 28939652›Full record

ArticleScience immunology2017

Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems.

William Santus, Simona Barresi, Francesca Mingozzi, Achille Broggi, Ivan Orlandi, Giulia Stamerra, Marina Vai, Alessandra M Martorana, Alessandra Polissi, Julia R Köhler and 3 more

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

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  16. Dermatophyte Immune Memory Is Only Skin-Deep.The Journal of investigative dermatology · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

William SantusDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.ORCID http://orcid.org/0000-0001-5940-3769
Simona BarresiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.ORCID http://orcid.org/0000-0002-9271-761X
Francesca MingozziDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.ORCID http://orcid.org/0000-0002-3484-0548
Achille BroggiHarvard Medical School and Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.
Ivan OrlandiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.ORCID http://orcid.org/0000-0002-5799-3213
Giulia StamerraDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.ORCID http://orcid.org/0000-0002-9802-8137
Marina VaiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.ORCID http://orcid.org/0000-0003-1729-2321
Alessandra M MartoranaDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.
Alessandra PolissiDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy.
Julia R KöhlerHarvard Medical School and Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.
Ningning LiuHarvard Medical School and Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.ORCID http://orcid.org/0000-0002-0546-3675
Ivan ZanoniDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. francesca.granucci@unimib.it ivan.zanoni@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-3423-7474
Francesca GranucciDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. francesca.granucci@unimib.it ivan.zanoni@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-7046-4914
University of Milano-Bicocca · ITBoston Children's Hospital · USUniversity of Milan · IT

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4M
Type III interferon Control of Mucosal ImmunityR01DK115217 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Scott B Snapper, Ivan Zanoni · 2017 to 2026
$5.6M
Innate control of the inflammatory process during fungal infectionsR01AI121066 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI ZANONI, IVAN · 2016 to 2025
$4.8M
The opportunist Candida albicans: yeast proliferation and nutritional signalingR01AI095305 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI KOEHLER, JULIA R · 2013 to 2017
$2.2M
NIAID NIH HHS R01 AI095305NIAID NIH HHS R01 AI121066NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK115217
6 · The paper itself

Abstract

Nuclear factor of activated T cells (NFAT) is activated in innate immune cells downstream of pattern recognition receptors, but little is known about NFAT's functions in innate immunity compared with adaptive immunity. We show that early activation of NFAT balances the two major phases of the innate response to

Identifiers

PMID28939652
PMCPMC5682945
OpenAlexW2760125379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.