Evidence map›Paper›PMID 28939595›Full record

ArticleThe Plant cell2017

Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.

Vera Gorelova, Jolien De Lepeleire, Jeroen Van Daele, Dick Pluim, Coline Meï, Ann Cuypers, Olivier Leroux, Fabrice Rébeillé, Jan H M Schellens, Dieter Blancquaert and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Plant cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 88 citations in OpenAlex.

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  16. B vitamin supply in plants and humans: the importance of vitamer homeostasis.The Plant journal : for cell and molecular biology · 2022
    Review
  17. Article
  18. Relative flux trade-offs and optimization of metabolic network functionalities.Computational and structural biotechnology journal · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Vera GorelovaDepartment of Biology, Laboratory of Functional Plant Biology, Ghent University, 9000 Gent, Belgium.
Jolien De LepeleireDepartment of Biology, Laboratory of Functional Plant Biology, Ghent University, 9000 Gent, Belgium.ORCID http://orcid.org/0000-0002-4761-1365
Jeroen Van DaeleLaboratory of Toxicology, Ghent University, 9000 Gent, Belgium.ORCID http://orcid.org/0000-0002-5738-8910
Dick PluimLaboratory of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Coline MeïLaboratoire de Physiologie Cellulaire Vegetale, UMR168 CNRS-CEA-INRA-Universite Joseph Fourier Grenoble I, Bioscience and Biotechnologies Institute of Grenoble, CEA-Grenoble, 38054 Grenoble Cedex 9, France.
Ann CuypersCentre for Environmental Sciences, Hasselt University, 3590 Diepenbeek, Belgium.ORCID http://orcid.org/0000-0002-0171-0245
Olivier LerouxDepartment of Biology, Ghent University, 9000 Gent, Belgium.ORCID http://orcid.org/0000-0001-9723-5604
Fabrice RébeilléLaboratoire de Physiologie Cellulaire Vegetale, UMR168 CNRS-CEA-INRA-Universite Joseph Fourier Grenoble I, Bioscience and Biotechnologies Institute of Grenoble, CEA-Grenoble, 38054 Grenoble Cedex 9, France.
Jan H M SchellensLaboratory of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Dieter BlancquaertDepartment of Biology, Laboratory of Functional Plant Biology, Ghent University, 9000 Gent, Belgium.
Christophe P StoveLaboratory of Toxicology, Ghent University, 9000 Gent, Belgium.ORCID http://orcid.org/0000-0001-7126-348X
Dominique Van Der StraetenDepartment of Biology, Laboratory of Functional Plant Biology, Ghent University, 9000 Gent, Belgium dominique.vanderstraeten@ugent.be.ORCID http://orcid.org/0000-0002-7755-1420
Ghent University · BECentre National de la Recherche Scientifique · FRThe Netherlands Cancer Institute · NLHasselt University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Folates (B9 vitamins) are essential cofactors in one-carbon metabolism. Since C1 transfer reactions are involved in synthesis of nucleic acids, proteins, lipids, and other biomolecules, as well as in epigenetic control, folates are vital for all living organisms. This work presents a complete study of a plant

Indexed as

HomeostasisArabidopsisArabidopsis ProteinsFolic AcidGene Expression Regulation, EnzymologicGene Expression Regulation, PlantIsoenzymesMutationNADPOxidation-ReductionPhylogenyPlants, Genetically ModifiedTetrahydrofolate DehydrogenaseThymidylate SynthaseArabidopsis ProteinsFolic AcidIsoenzymesNADPTetrahydrofolate DehydrogenaseThymidylate Synthase

Identifiers

PMID28939595
PMCPMC5728131
OpenAlexW2756555302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.