Evidence map›Paper›PMID 28939593›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Boosted coupling of ATP hydrolysis to substrate transport upon cooperative estradiol-17-β-D-glucuronide binding in a Drosophila ATP binding cassette type-C transporter.

Agnes Karasik, Kaitlyn Victoria Ledwitch, Tamás Arányi, András Váradi, Arthur Roberts, Flóra Szeri

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Agnes KarasikInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Kaitlyn Victoria LedwitchDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, USA.
Tamás ArányiInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
András VáradiInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Arthur RobertsDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, USA.
Flóra SzeriInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
HUN-REN Research Centre for Natural Sciences · HUUniversity of Georgia · USHungarian Academy of Sciences · HUInstitute of Molecular Life Sciences · HU

Funding

TRAINING PROGRAM IN ION CHANNEL AND TRANSPORTER BIOLOGYT32NS007491 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENTON, JEROD S. · 2001 to 2020
$4.1M
Overcoming Cancer Resistance Mediated by the Human MDR1 TransporterR01CA204846 · NCI · UNIVERSITY OF GEORGIA · PI ROBERTS, ARTHUR G · 2017 to 2021
$1.9M
NCI NIH HHS R01 CA204846NINDS NIH HHS T32 NS007491
6 · The paper itself

Abstract

ATP binding cassette type-C (ABCC) transporters move molecules across cell membranes upon hydrolysis of ATP; however, their coupling of ATP hydrolysis to substrate transport remains elusive. Drosophila multidrug resistance-associated protein (DMRP) is the functional ortholog of human long ABCC transporters, with similar substrate and inhibitor specificity, but higher activity. Exploiting its high activity, we kinetically dissected the catalytic mechanism of DMRP by using E

Indexed as

Adenosine TriphosphateAllosteric RegulationAnimalsATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersDrosophila melanogasterDrosophila ProteinsEstradiolHumansHydrolysisMultidrug Resistance-Associated Protein 2ABCC2 protein, humanAdenosine TriphosphateATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersDrosophila ProteinsEstradiolestradiol-17 beta-glucuronideMRP protein, DrosophilaMultidrug Resistance-Associated Protein 2allosteric cooperativityCOPASIDrosophila MRPE2G transportkinetic modeling

Identifiers

PMID28939593
PMCPMC6137642
OpenAlexW2758708279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.