Evidence map›Paper›PMID 28939492›Full record

Trial reportReproductive toxicology (Elmsford, N.Y.)2017

Triclosan and triclocarban exposure and thyroid function during pregnancy-A randomized intervention.

Catherine Ley, Lauren Pischel, Julie Parsonnet

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Reproductive toxicology (Elmsford, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01442701 (Stanford's Outcomes Research in Kids), which is not on this map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01442701 completednot on this map

Stanford's Outcomes Research in Kids (STORK)

TypeobservationalSponsorStanford UniversityRan2011 to 2019Enrolled361ConditionsBacterial, Viral and Other Infectious AgentsArmsRemoval of triclosan-containing cleaning products from household.
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Are Wild Boars Exposed to Triclosan and Triclocarban?Animals : an open access journal from MDPI · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Triclosan: A Small Molecule with Controversial Roles.Antibiotics (Basel, Switzerland) · 2022
    Review
  10. Stannous Fluoride Effects on Enamel: A Systematic Review.Biomimetics (Basel, Switzerland) · 2020
    Review
  11. Article
  12. Impact of prenatal triclosan exposure on gestational age and anthropometric measures at birth: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Catherine LeyDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, United States. Electronic address: cley@stanford.edu.
Lauren PischelDivision of Epidemiology, Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA 94305, United States.
Julie ParsonnetDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, United States; Division of Epidemiology, Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA 94305, United States.
Stanford Medicine · US

Funding

Childhood infection and prevention of obesityR01HD063142 · NICHD · STANFORD UNIVERSITY · PI PARSONNET, JULIE · 2009 to 2013
$3.7M
Household Triclosan and Triclocarban Use and the Developing Infant MicrobiomeR21ES023371 · NIEHS · STANFORD UNIVERSITY · PI PARSONNET, JULIE · 2014 to 2016
$974k
NICHD NIH HHS R01 HD063142NIEHS NIH HHS R21 ES023371
6 · The paper itself

Abstract

Triclosan and triclocarban (TCs) are broad-spectrum microbicides found in household and personal wash products. We sought to determine whether TC exposure from wash products or urinary triclosan level modified thyroid function during pregnancy or anthropometric measurements at birth. A randomized intervention of wash products with or without TCs, including toothpaste, enrolled pregnant women from 20 weeks' gestation. Urinary triclosan, TSH, T4 and T3 were assessed at enrollment, 36weeks' gestation and/or post-delivery; anthropometric measures at birth were ascertained from medical records. 78 and 76 mothers were assigned to the TC-containing and no-TC-containing product arms, respectively. No differences were observed in any thyroid function measure at any time point or in any anthropometric measurement at birth between either exposure arms or lowest and highest urinary triclosan quartile groups. TCs from wash products, primarily liquid and bar soaps, did not affect thyroid function measures during pregnancy or babies' anthropometric measures at delivery.

Indexed as

Maternal ExposureAnti-Infective Agents, LocalBody Weights and MeasuresCarbanilidesCosmeticsFemaleHumansInfant, NewbornMaleMaternal-Fetal ExchangePregnancyThyroid GlandThyrotropinThyroxineTriclosanTriiodothyronineAnti-Infective Agents, LocalCarbanilidesCosmeticsThyrotropinThyroxinetriclocarbanTriclosanTriiodothyronineAnthropometryPregnancyRandomized interventionThyroid functionTriclocarbanTriclosan

Identifiers

PMID28939492
PMCPMC5718922
OpenAlexW2753951399

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.