Evidence map›Paper›PMID 28939455›Full record

ReviewBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2018

Neurocognitive Dysfunction in Hematopoietic Cell Transplant Recipients: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Complications and Quality of Life Working Party of the European Society for Blood and Marrow Transplantation.

Debra Lynch Kelly, David Buchbinder, Rafael F Duarte, Jeffrey J Auletta, Neel Bhatt, Michael Byrne, Zachariah DeFilipp, Melissa Gabriel, Anuj Mahindra, Maxim Norkin and 37 more

Abstract readReview
In one paragraph

Review in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Cognitive Function and Quality of Life in Vorinostat-Treated Patients after Matched Unrelated Donor Myeloablative Conditioning Hematopoietic Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Predictive risk model of mild cognitive impairment in patients with malignant haematological diseases after haematopoietic stem cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Debra Lynch KellyShands HealthCare and University of Florida, Gainesville, Florida. Electronic address: dlynchkelly@ufl.edu.
David BuchbinderDivsison of Pediatrics Hematology, Children's Hospital of Orange County, Orange, California.
Rafael F DuarteUniversity Hospital Puerta de Hierro, Madrid, Spain.
Jeffrey J AulettaBlood and Marrow Transplant Program and Host Defense Program, Division of Hematology, Nationwide Children's Hospital, Columbus, Ohio; Blood and Marrow Transplant Program and Host Defense Program, Division of Oncology, Nationwide Children's Hospital, Columbus, Ohio; Blood and Marrow Transplant Program and Host Defense Program, Division of Bone Marrow Transplant and Infectious Diseases, Nationwide Children's Hospital, Columbus, Ohio.
Neel BhattCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Michael ByrneVanderbilt University Medical Center, Nashville, Tennessee.
Zachariah DeFilippBlood and Marrow Transplant Program, Massachusetts General Hospital, Boston, Massachusetts.
Melissa GabrielThe Children's Hospital at Westmead, New South Wales, Australia.
Anuj MahindraScripps Blood & Marrow Transplant Program, La Jolla, California.
Maxim NorkinShands HealthCare and University of Florida, Gainesville, Florida.
Helene SchoemansUniversity Hospital of Leuven, Leuven, Belgium.
Ami J ShahDivision of Stem Cell Transplantation and Regenerative Medicine, Lucille Packard Children's Hospital, Stanford School of Medicine, Palo Alto, California.
Ibrahim AhmedDivision of Pediatric Hem/Onc/BMT, Children's Mercy Kansas City, Kansas City, Missouri; UMKC School of Medicine, Kansas City, Missouri.
Yoshiko AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan; Nagoya University Graduate School of Medicine, Nagoya, Japan.
Grzegorz W BasakMedical University of Warsaw, Warsaw, Poland.
Sara BeattieDepartment of Psychosocial Oncology and Rehabilitation, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
Sita BhellaDepartment of Psychosocial Oncology and Rehabilitation, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
Christopher BredesonOttawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Nancy BuninChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Jignesh DalalCase Western Reserve School of Medicine, Cleveland, Ohio; Rainbow Babies and Children's Hospital, Cleveland, Ohio.
Andrew DalyTom Baker Cancer Centre, Calgary, Alberta, Canada.
James GajewskiOregon Health and Science University, Portland, Oregon.
Robert Peter GaleDivision of Experimental Medicine, Department of Medicine, Imperial College London, Hematology Research Centre, London, United Kingdom.
John GalvinDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Mehdi HamadaniCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Robert J HayashiDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Kehinde AdekolaDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Jason LawTufts University Medical Center, Boston, Massachusetts.
Catherine J LeeUtah Blood and Marrow Transplant Program Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Jane LiesveldDepartment of Medicine, University of Rochester Medical Center, Rochester, New York.
Adriana K MaloneTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Arnon NaglerHematology Division and BMT, Chaim Sheba Medical Center, Tel Hashomer, Israel; Tel Aviv University, Tel Aviv, Israel.
Seema NaikTexas Transplant Institute, San Antonino, Texas.
Taiga NishihoriDepartment of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Susan K ParsonsTufts University Medical Center, Boston, Massachusetts.
Angela ScherwathDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hannah-Lise SchofieldPennsylvania State University, University Park, Pennsylvania.
Robert SoifferDana Farber Cancer Institute, Boston, Massachusetts.
Jeff SzerDepartment Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia.
Ida TwistThe Children's Hospital at Westmead, New South Wales, Australia.
Anne WarwickDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Baldeep M WirkDivision of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, Washington.
Jean YiClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Minoo BattiwallaHematopoietic Transplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Mary E FlowersClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Bipin SavaniBlood and Marrow Transplant Program, Massachusetts General Hospital, Boston, Massachusetts.
Bronwen E ShawCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
NCI NIH HHS U24 CA076518NHLBI NIH HHS U10 HL069294
6 · The paper itself

Abstract

Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and nonmalignant diseases. Despite increasing survival rates, long-term morbidity after HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction after HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction after HCT. In this review we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Finally, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae after HCT.

Indexed as

BiomarkersHematopoietic Stem Cell TransplantationHumansNeurocognitive DisordersPrevalenceRisk FactorsBiomarkersBone marrow transplantationCognitionCognitive functionHematology oncologyHematopoietic cell transplantationNeurocognitive dysfunction

Identifiers

PMID28939455
PMCPMC5768142

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.