Evidence map›Paper›PMID 28939057›Full record

ArticleBiochimica et biophysica acta. Molecular cell research2018

The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability.

William Grey, Adam Ivey, Thomas A Milne, Torsten Haferlach, David Grimwade, Frank Uhlmann, Edwige Voisset, Veronica Yu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular cell research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

William GreyDepartment of Medical and Molecular Genetics, King's College London, Faculty of Life Sciences and Medicine, London, UK. Electronic address: william.grey@crick.ac.uk.
Adam IveyDepartment of Medical and Molecular Genetics, King's College London, Faculty of Life Sciences and Medicine, London, UK.
Thomas A MilneMRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Programme, University of Oxford, UK.
Torsten HaferlachMLL Munich Leukemia Laboratory, Munich, Germany.
David GrimwadeDepartment of Medical and Molecular Genetics, King's College London, Faculty of Life Sciences and Medicine, London, UK.
Frank UhlmannChromosome Segregation Laboratory, The Francis Crick Institute, London, UK.
Edwige VoissetDepartment of Medical and Molecular Genetics, King's College London, Faculty of Life Sciences and Medicine, London, UK. Electronic address: edwige.voisset@kcl.ac.uk.
Veronica YuDepartment of Medical and Molecular Genetics, King's College London, Faculty of Life Sciences and Medicine, London, UK.
King's College London · GBMunich Leukemia Laboratory (Germany) · DEThe Francis Crick Institute · GBUniversity of Oxford · GB

Funding

Medical Research Council MC_UU_00016/6Medical Research Council MC_UU_12009/6
6 · The paper itself

Abstract

The Cdc28 protein kinase subunits, Cks1 and Cks2, play dual roles in Cdk-substrate specificity and Cdk-independent protein degradation, in concert with the E3 ubiquitin ligase complexes SCF

Indexed as

AnimalsCarrier ProteinsCDC28 Protein Kinase, S cerevisiaeCDC2-CDC28 KinasesCell Cycle ProteinsCells, CulturedCell SurvivalEmbryo, MammalianGene Expression Regulation, LeukemicGene RearrangementHistone-Lysine N-MethyltransferaseHumansLeukemiaMiceMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionCarrier ProteinsCDC28 Protein Kinase, S cerevisiaeCDC2-CDC28 KinasesCell Cycle ProteinsCKS1B protein, humanCks1 protein, mouseCKS2 protein, humanCks2 protein, mouseHistone-Lysine N-MethyltransferaseKMT2A protein, humanMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionCKS1BCKS2MLL1MLL-fusion proteinsSKP2/CKS1 inhibitorWnt

Identifiers

PMID28939057
PMCPMC5701546
OpenAlexW2754249713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.