Foreseeing the future of glomerular disease through slits: miR-NPNT axis.

Reiko Inagi, Yu Ishimoto, Tzu-Ming Jao

Open access · bronzeAbstract readComment

In one paragraph

Article in Kidney international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

0.2field-weighted citation impact, top 45% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

Expression of Nephronectin in the Descemet's membrane of mouse corneas during development and adult homeostasis.Experimental eye research · 2024
Article
Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development.eLife · 2022
Article
A Tight Control of Non-Canonical TGF-β Pathways and MicroRNAs Downregulates Nephronectin in Podocytes.Cells · 2022
Article
Homocysteine induces podocyte apoptosis by regulating miR-1929-5p expression through c-Myc, DNMT1 and EZH2.Molecular oncology · 2021
Article
Upregulated microRNAs in membranous glomerulonephropathy are associated with significant downregulation of IL6 and MYC mRNAs.Journal of cellular physiology · 2019
Article

4 · The record

Corrections and comments

Comment on
Podocytes regulate the glomerular basement membrane protein nephronectin by means of miR-378a-3p in glomerular diseases.2017

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Reiko InagiDivision of CKD Pathophysiology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. Electronic address: inagi-npr@umin.ac.jp.

Yu IshimotoDivision of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Tzu-Ming JaoDivision of CKD Pathophysiology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

The University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Podocyte biology is an important key factor for the maintenance of glomerular function and structure. Nephronectin is a podocyte-derived extracellular matrix protein in the glomerular basement membrane. Suppression of nephronectin expression by microRNA-378a-3p significantly induced proteinuria due to loss of integrity of the glomerular filtration barrier in zebrafish and mice, demonstrating the relevance of the microRNA-nephronectin axis in regulation of the podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier.

Indexed as

MicroRNAsPodocytesAnimalsExtracellular Matrix ProteinsGlomerular Basement MembraneMiceProteinuriaExtracellular Matrix ProteinsMicroRNAsnephronectin

Identifiers

PMID28938947

DOI10.1016/j.kint.2017.04.036

OpenAlexW2755391616

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.