ArticleJournal of medical case reports2017
Clozapine-induced acute gastrointestinal necrosis: a case report.
Article in Journal of medical case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Markers of Prognosis for Acute Esophageal Necrosis: A Systematic Review.Digestive diseases (Basel, Switzerland) · 2025Pooled it
- Severe antipsychotic-associated gastrointestinal hypomotility: AMSP pharmacovigilance data from 333,175 psychiatric inpatients.European archives of psychiatry and clinical neuroscience · 2026Article
- Quetiapine-induced paralytic ileus in a male patient in his 40s with polypharmacy.Journal of rural medicine : JRM · 2026Article
- Article
- Esophagitis after Clozapine Use in a 61-Year-Old Woman with Refractory Schizophrenia.Case reports in psychiatry · 2022Article
- Clozapine-Induced Constipation: A Case Report and Review of Current Management Guidelines.Cureus · 2021Article
- Atypical Presentation of Acquired Hypoganglionosis in a Patient Taking Clozapine.Case reports in gastrointestinal medicine · 2020Article
- Comprehensive review of acute oesophageal necrosis.BMJ case reports · 2019Article
- Diagnosis and management of acute esophageal necrosis.Annals of gastroenterologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClozapine is known to cause fecal impaction and ileus with resultant colonic necrosis due to compression of colonic mucosa. There are rare reports of clozapine causing necrosis of other portions of the gastrointestinal tract unrelated to constipation. We describe a case of acute necrosis of the upper gastrointestinal tract and small bowel to due to clozapine and quetiapine. CASE PRESENTATION: A 66-year-old white man with a past medical history of schizophrenia, maintained on clozapine and quetiapine, presented with hypoxic respiratory failure caused by aspiration of feculent emesis due to impacted stool throughout his colon. His constipation resolved with discontinuation of clozapine and quetiapine, and his clinical condition improved. These medicines were restarted after 2 weeks, resulting in acute gastrointestinal necrosis from the mid esophagus through his entire small bowel. He died due to septic shock with Gram-negative rod bacteremia.
conclusionsClozapine may cause acute gastrointestinal necrosis.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.