Evidence map›Paper›PMID 28938794›Full record

SynthesisNutrition reviews2017

Association between plant-based diets and plasma lipids: a systematic review and meta-analysis.

Yoko Yokoyama, Susan M Levin, Neal D Barnard

2 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrition reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 138 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 16 pooled it
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05889715 nacompletednot on this mapstarted 2023, after this paper: background citation

An Interprofessional-led Model of Care to Prevent and Treat Chronic Diseases Using a Whole Food, Plant-based Nutrition Program in a Primary Care Setting

TypeinterventionalSponsorThe University of Texas Health Science Center at San AntonioRan2023 to 2024Enrolled47ConditionsChronic Disease, Nutrition, HealthyArmsGreen Wellness Program: Plants-2-Plate
NCT07095543 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Feasibility, Implementation, and Efficacy of a Plant-based Online Weight Loss Through Education and Resources Program and Study (POWER Study)

TypeinterventionalSponsorPhysicians Committee for Responsible MedicineRan2025 to 2028Enrolled100ConditionsType 2 Diabetes, Overweight and Obese AdultsArmsLow-fat, vegan diet
3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 16 syntheses or guidelines pooled it, 305 citations in OpenAlex.

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  8. Effects of vegan diets on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Yoko YokoyamaGraduate School of Media and Governance, Keio University, Fujisawa, Kanagawa, Japan.
Susan M LevinPhysicians Committee for Responsible Medicine, Washington, DC, USA.
Neal D BarnardPhysicians Committee for Responsible Medicine, Washington, DC, USA.
George Washington University · USKeio University Shonan Fujisawa · JPPhysicians Committee for Responsible Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextAlthough a recent meta-analysis of randomized controlled trials showed that adoption of a vegetarian diet reduces plasma lipids, the association between vegetarian diets and long-term effects on plasma lipids has not been subjected to meta-analysis.

objectiveThe aim was to conduct a systematic review and meta-analysis of observational studies and clinical trials that have examined associations between plant-based diets and plasma lipids. DATA SOURCES: MEDLINE, Web of Science, and the Cochrane Central Register of Controlled Trials were searched for articles published in English until June 2015. STUDY SELECTION: The literature was searched for controlled trials and observational studies that investigated the effects of at least 4 weeks of a vegetarian diet on plasma lipids. DATA EXTRACTION: Two reviewers independently extracted the study methodology and sample size, the baseline characteristics of the study population, and the concentrations and variance measures of plasma lipids. Mean differences in concentrations of plasma lipids between vegetarian and comparison diet groups were calculated. Data were pooled using a random-effects model.

resultsOf the 8385 studies identified, 30 observational studies and 19 clinical trials met the inclusion criteria (N = 1484; mean age, 48.6 years). Consumption of vegetarian diets was associated with lower mean concentrations of total cholesterol (-29.2 and -12.5 mg/dL, P < 0.001), low-density lipoprotein cholesterol (-22.9 and -12.2 mg/dL, P < 0.001), and high-density lipoprotein cholesterol (-3.6 and -3.4 mg/dL, P < 0.001), compared with consumption of omnivorous diets in observational studies and clinical trials, respectively. Triglyceride differences were -6.5 (P = 0.092) in observational studies and 5.8 mg/dL (P = 0.090) in intervention trials.

conclusionsPlant-based diets are associated with decreased total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, but not with decreased triglycerides. SYSTEMATIC REVIEW REGISTRATION: PROSPERO number CRD42015023783. Available at: https://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015023783.

Indexed as

Diet, VegetarianCholesterol, HDLCholesterol, LDLDatabases, FactualDiet, VeganHumansObservational Studies as TopicRandomized Controlled Trials as TopicTriglyceridesCholesterol, HDLCholesterol, LDLTriglycerideshigh-density lipoprotein cholesterollow-density lipoprotein cholesterolmeta-analysisplant-based dietsplasma lipidssystematic reviewtotal cholesterol

Identifiers

PMID28938794
PMCPMC5914369
OpenAlexW2745817505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.