Evidence map›Paper›PMID 28938290›Full record

ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2017

Body Composition Changes in Severely Burned Children During ICU Hospitalization.

Janos Cambiaso-Daniel, Ioannis Malagaris, Eric Rivas, Gabriel Hundeshagen, Charles D Voigt, Elizabeth Blears, Ron P Mlcak, David N Herndon, Celeste C Finnerty, Oscar E Suman

Abstract read
In one paragraph

Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Rehabilitative Exercise Training for Burn Injury.Sports medicine (Auckland, N.Z.) · 2021
    Review
  8. Article
  9. Current problems in burn hypermetabolism.Current problems in surgery · 2020
    Review
  10. The Long-Term Impact of Severe Burn Trauma on Musculoskeletal Health.Journal of burn care & research : official publication of the American Burn Association · 2018
    Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Janos Cambiaso-DanielDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Ioannis MalagarisShriners Hospitals for Children - Galveston, Galveston, TX.
Eric RivasDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Gabriel HundeshagenDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Charles D VoigtDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Elizabeth BlearsDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Ron P MlcakDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
David N HerndonDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Celeste C FinnertyDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Oscar E SumanDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.

Funding

UTMB Clinical and Translational Science AwardUL1TR001439 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI URBAN, RANDALL J · 2015 to 2024
$40.0M
Project 9: The role of androgen/corticosteroid in fat, muscle and glucose metabolism of burn victimsP50GM060338 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HERNDON, DAVID N. · 2000 to 2017
$24.2M
MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSER01GM056687 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HERNDON, DAVID N. · 1998 to 2017
$9.0M
Oxandrolone and Exercise: A potent therapy in the rehabilitation from burnsR01HD049471 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUMAN-VEJAS, OSCAR E. · 2006 to 2019
$5.8M
POSTDOCTORAL TRAINING IN TRAUMA &BURNST32GM008256 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Celeste Campbell Finnerty, Oscar E. Suman-Vejas · 1990 to 2026
$4.0M
Effects of Chronic Catecholamine Exposure on Post-burn ScarringR01GM112936 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FINNERTY, CELESTE CAMPBELL · 2015 to 2019
$1.8M
NCATS NIH HHS UL1 TR001439NICHD NIH HHS R01 HD049471NIGMS NIH HHS P50 GM060338NIGMS NIH HHS R01 GM056687NIGMS NIH HHS R01 GM112936NIGMS NIH HHS T32 GM008256
6 · The paper itself

Abstract

objectivesProlonged hospitalization due to burn injury results in physical inactivity and muscle weakness. However, how these changes are distributed among body parts is unknown. The aim of this study was to evaluate the degree of body composition changes in different anatomical regions during ICU hospitalization.

designRetrospective chart review.

settingChildren's burn hospital. PATIENTS: Twenty-four severely burned children admitted to our institution between 2000 and 2015.

interventionsAll patients underwent a dual-energy x-ray absorptiometry within 2 weeks after injury and 2 weeks before discharge to determine body composition changes. No subject underwent anabolic intervention. We analyzed changes of bone mineral content, bone mineral density, total fat mass, total mass, and total lean mass of the entire body and specifically analyzed the changes between the upper and lower limbs. MEASUREMENTS AND MAIN

resultsIn the 24 patients, age was 10 ± 5 years, total body surface area burned was 59% ± 17%, time between dual-energy x-ray absorptiometries was 34 ± 21 days, and length of stay was 39 ± 24 days. We found a significant (p < 0.001) average loss of 3% of lean mass in the whole body; this loss was significantly greater (p < 0.001) in the upper extremities (17%) than in the lower extremities (7%). We also observed a remodeling of the fat compartments, with a significant whole-body increase in fat mass (p < 0.001) that was greater in the truncal region (p < 0.0001) and in the lower limbs (p < 0.05).

conclusionsICU hospitalization is associated with greater lean mass loss in the upper limbs of burned children. Mobilization programs should include early mobilization of upper limbs to restore upper extremity function.

Indexed as

HospitalizationAbsorptiometry, PhotonAdolescentBody CompositionBurnsChildEnergy MetabolismFemaleHumansIntensive Care Units, PediatricMaleMuscle, SkeletalMuscle StrengthRetrospective Studies

Identifiers

PMID28938290
PMCPMC5716837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.