SynthesisJournal of orthopaedic trauma2017
Tranexamic Acid in Orthopaedic Trauma Surgery: A Meta-Analysis.
Synthesis in Journal of orthopaedic trauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Tranexamic Acid (TXA) in Humerus ORIF
Effect of Tranexamic Acid on Perioperative Blood Loss in Reamed Intramedullary Nailing of Diaphyseal Femoral and Tibial Fractures: A Prospective Comparative Study.
Who cites it
45 citing papers in PubMed, 7 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Tranexamic acid in radical cystectomy: a systematic review and meta-analysis of efficacy and safety.World journal of urology · 2025Pooled it
- Tranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis.Aesthetic surgery journal · 2025Pooled it
- Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions: A Meta-Analysis.JAMA network open · 2024Pooled it
- Effect of Tranexamic Acid on Blood Management during a High Tibial Osteotomy: A Systematic Review and Meta-analysis.Orthopaedic surgery · 2022Pooled it
- Efficacy and Safety of Tranexamic Acid in Reducing Blood Loss of Lower Extremity Osteotomy in Peri-acetabulum and High Tibia: A Systematic Review and Meta-analysis.Orthopaedic surgery · 2019Pooled it
- Efficacy and Safety of Tranexamic Acid for Blood Salvage in Intertrochanteric Fracture Surgery: A Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Pooled it
- Preoperative Tranexamic Acid for Treatment of Bleeding, Edema, and Ecchymosis in Patients Undergoing Rhinoplasty: A Systematic Review and Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2018Pooled it
- A randomized control trial on the role of tranexamic acid in preventing intraoperative bleeding during external dacryocystorhinostomy.Indian journal of ophthalmology · 2022Trial
- Is intravenous tranexamic acid effective in reduction of blood loss during pelvic and acetabular surgery?International orthopaedics · 2022Trial
- Trial
- Tranexamic acid in shoulder surgery: a narrative review.JSES reviews, reports, and techniques · 2026Review
- Association of tranexamic acid use and autologous predonation with blood loss and transfusion outcomes after periacetabular osteotomy: An arm-based multilevel meta analysis.Journal of experimental orthopaedics · 2026Review
- Role of Tranexamic Acid in Orthopedic Trauma: Current Evidence, Clinical Applications, and Ongoing Controversies.Journal of orthopaedic case reports · 2026Article
- Effect of Tranexamic Acid on Inpatient Admission and Revision Rates in Primary Rhinoplasty: A Propensity Score-Matched Analysis.Plastic and reconstructive surgery. Global open · 2026Article
- Evaluation of Tranexamic Acid for the Reduction of Blood Loss During Burn Surgery in Adults (Tranburn Study).Annals of burns and fire disasters · 2025Article
- Intravenous Injection of Tranexamic Acid in Patients with Pelvic Fractures: A Prospective Randomized Trial.Hip & pelvis · 2025Article
- Efficacy of small-diameter core decompression with platelet-rich plasma in early osteonecrosis of the femoral head: a retrospective study.BMC musculoskeletal disorders · 2025Article
- Use of Oral and Intravenous Tranexamic Acid in Total Knee Arthroplasty and Total Hip Arthroplasty Procedures.Cureus · 2024Article
- [Effect of intravenous tranexamic acid on postoperative drainage and elbow joint function after traumatic elbow stiffness release].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Article
- Efficacy and safety of tranexamic acid use in elderly patients undergoing anterior cervical discectomy and fusion: a retrospective study.The Journal of international medical research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo systematically review and quantify the efficacy of tranexamic acid (TXA) use in reducing the risk of receiving a blood transfusion in patients undergoing orthopaedic trauma surgery, in reducing blood loss, and risk of thromboembolic events.
methodsA systematic literature search was performed using MEDLINE, Embase, ClinicalTrials.gov, and conference proceeding abstracts from 2014 to 2016. A minimum of 2 reviewers screened each study and graded quality. The primary outcome measure was the risk of receiving a blood transfusion in the TXA group versus control. A meta-analysis was performed to construct a combined odds ratio (OR) of receiving a blood transfusion, mean difference (MD) of blood loss, and OR of thromboembolic events.
resultsTwelve studies were included in the quantitative analysis (1,333 patients). The risk of blood transfusion was significantly less in patients who were administered TXA compared with controls [OR 0.407; 95% confidence interval (CI) 0.278-0.594, I = 34, Q = 17, P ≤ 0.001]. There was significantly less blood loss in the TXA group compared with controls, as the mean difference was 304 mL (95% CI, 142-467 mL) (I = 94, Q value = 103, P < 0.001). There was no significant difference in risk of symptomatic thromboembolic events (OR 0.968; 95% CI, 0.530-1.766, I = 0, Q value = 5, P = 0.684).
conclusionsIn patients with orthopaedic trauma, TXA reduces the risk of blood transfusion, reduces perioperative blood loss, and has no significant effect on the risk of symptomatic thromboembolic events. More high-quality studies are needed to ensure the safety of the drug in these patients. LEVEL OF EVIDENCE: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.