ArticleDrug and alcohol dependence2017
Preliminary evidence that reactivity to uncertain threat is an endophenotype for alcohol use disorder.
Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Longitudinal associations between binge drinking and changes in behavioral and neural threat reactivity in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Altered Effective Connectivity During Threat Anticipation in Individuals With Alcohol Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Neural responses to reward, threat, and emotion regulation and transition to hazardous alcohol use.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Sleep quality impacts the link between reactivity to uncertain threat and anxiety and alcohol use in youth.Psychophysiology · 2024Article
- Impact of handgun ownership and biological sex on startle reactivity to predictable and unpredictable threats.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- NEURAL RESPONSE TO THREAT AND REWARD AMONG YOUNG ADULTS AT RISK FOR ALCOHOL USE DISORDER.medRxiv : the preprint server for health sciences · 2023Article
- Behavioral and brain reactivity to uncertain stress prospectively predicts binge drinking in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Hispanic/Latinx ethnic differences in the relationships between behavioral inhibition, anxiety, and substance use in youth from the ABCD cohort.Frontiers in psychiatry · 2023Article
- Association between startle reactivity to uncertain threats and structural brain volume.Psychophysiology · 2022Article
- Alcohol's effects during uncertain and uncontrollable stressors in the laboratory.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Childhood Adversity and the Association Between Stress Sensitivity and Problematic Alcohol Use in Adults.Journal of traumatic stress · 2022Article
- Stress Allostasis in Substance Use Disorders: Promise, Progress, and Emerging Priorities in Clinical Research.Annual review of clinical psychology · 2020Review
- Behavioral and neural sensitivity to uncertain threat in individuals with alcohol use disorder: Associations with drinking behaviors and motives.Addiction biology · 2020Article
- Human Plasma BDNF Is Associated With Amygdala-Prefrontal Cortex Functional Connectivity and Problem Drinking Behaviors.The international journal of neuropsychopharmacology · 2020Article
- Interpersonal trauma exposure and startle reactivity to uncertain threat in individuals with alcohol use disorder.Drug and alcohol dependence · 2020Article
- Startle during threat longitudinally predicts functional impairment independent of DSM diagnoses.Psychiatry research · 2019Article
- Sex and β-Endorphin Influence the Effects of Ethanol on LimbicFrontiers in genetics · 2018Article
- Transdiagnostic physiological correlates of unpredictable threat anticipation.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHaving an exaggerated reactivity to threats that are uncertain (U-threat) may facilitate the initiation and maintenance of excessive alcohol use in some individuals. This abnormality may not just be a concomitant for alcohol use disorder (AUD), but also an endophenotype for AUD.
methodThe aim of the current study was therefore to provide a preliminary test of whether U-threat is an endophenotype for AUD using several of the endophenotype criteria outlined by Gottesman and Gould (2003). Specifically, the study examined whether heightened U-threat reactivity is evidenced in those with: 1) current AUD; 2) remitted AUD (early and sustained remission examined separately); and 3) at-risk for AUD by virtue of having a positive family history of AUD. Participants (N = 147) completed a well-validated threat-of-shock task and startle eyeblink potentiation was collected as an index of aversive responding. Individuals and all available first-degree family members were diagnosed using structured clinical interviews.
resultsIndividuals at-risk for AUD, with current AUD, and AUD in remission (both early and sustained) all displayed exaggerated reactivity to U-threat, but not predictable threat, compared with non-AUD controls. Moreover, there were no significant differences between the at-risk and any of the AUD groups indicating that exaggerated reactivity to U-threat is relatively state-independent and present regardless of current AUD disease status.
conclusionsThe findings together highlight that exaggerated reactivity to U-threat may be a promising endophenotype for AUD that can aid in the refinement of mechanistic AUD disease models.
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