ArticleCell2017
Prion-like Domains Program Ewing's Sarcoma.
Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Biomolecular condensates as dynamic regulators of musculoskeletal homeostasis, disease, and therapeutic challenges.Bone research · 2026Review
- Suppressing the Aberrant Transcriptional Functionality of EWS::FLI1 Oncoprotein by Designer polyQ Fusions with Its Homologous Peptides.Biomedicines · 2026Article
- Transcription regulation by biomolecular condensates.Nature reviews. Molecular cell biology · 2025Review
- Long way up: rethink diseases in light of phase separation and phase transition.Protein & cell · 2024Review
- Modulating gene regulation function by chemically controlled transcription factor clustering.Nature communications · 2022Article
- FUS oncofusion protein condensates recruit mSWI/SNF chromatin remodeler via heterotypic interactions between prion-like domains.Protein science : a publication of the Protein Society · 2021Article
- Biochemical Timekeeping Via Reentrant Phase Transitions.Journal of molecular biology · 2021Review
- Computational Screening of Phase-separating Proteins.Genomics, proteomics & bioinformatics · 2021Review
- Microfluidic characterization of macromolecular liquid-liquid phase separation.Lab on a chip · 2020Article
- FGviewer: an online visualization tool for functional features of human fusion genes.Nucleic acids research · 2020Article
- Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma.The Journal of biological chemistry · 2019Article
- Intrinsic Disorder-Based Emergence in Cellular Biology: Physiological and Pathological Liquid-Liquid Phase Transitions in Cells.Polymers · 2019Review
- The molecular language of membraneless organelles.The Journal of biological chemistry · 2019Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcriptional programs underlying Ewing's sarcoma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.