ArticleZeitschrift fur Naturforschung. C, Journal of biosciences2018
Diverse bioactive compounds from Sarcophtyton glaucom: structure elucidation and cytotoxic activity studies.
Article in Zeitschrift fur Naturforschung. C, Journal of biosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Article
- Cytotoxic Compounds from Alcyoniidae: An Overview of the Last 30 Years.Marine drugs · 2022Review
- Cembranoids of Soft Corals: Recent Updates and Their Biological Activities.Natural products and bioprospecting · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical investigation of the Red Sea soft coral Sarcophyton glaucom collected at the coasts of Hurghada, Egypt, led to the isolation of one new naturally occurring 4-oxo-1,1′-pentanoic acid anhydride (1), along with four diterpenes; sarcophinone (2a), 8-epi-sarcophinone (2b), (+)-7α,8β-dihydroxydeepoxysarcophine (3), sinumaximol G (4), (+)-sarcophine (5), sesquiterpene; prostantherol (6), sterol; 3β,24S-ergost-5-en-ol (7) and hexadecanoic acid. The structures of the obtained compounds were established using diverse spectroscopic techniques including 1D and 2D NMR and HRMS. Biologically, in vitro cytotoxic activities of diterpenes 2–5 and prostantherol (6) were studied against the liver cancer HEPG2 cell line in comparison with the soft coral extract and doxorubicin as reference (IC50: 4.28 μg/mL). Compounds 2–6 exhibited potent–moderate cytotoxicity of IC50 between 9.97 μg/mL [for sinumaximol G (4)] and 17.84 μg/mL [for (+)-7α,8β-dihydroxydeepoxysarcophine (3)], whereas that for soft coral extract was determined at 24.71 μg/mL.
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Registered trials
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