Evidence map›Paper›PMID 28937955›Full record

ArticleJournal of neurotrauma2017

Military Blast Injury and Chronic Neurodegeneration: Research Presentations from the 2015 International State-of-the-Science Meeting.

Denes Agoston, Peethambaran Arun, Patrick Bellgowan, Steven Broglio, Robert Cantu, David Cook, Uade Olaghere da Silva, Dara Dickstein, Gregory Elder, Elizabeth Fudge and 15 more

Abstract readConference Proceedings
In one paragraph

Article in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Altered Serotonin 2A (5-HTFrontiers in pharmacology · 2022
    Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Denes Agoston1 Uniformed Services University of the Health Sciences , Bethesda, Maryland.
Peethambaran Arun2 Walter Reed Army Institute of Walter Reed Army Institute of Research , Silver Spring, Maryland.
Patrick Bellgowan3 National Institute of Neurological Disorders and Stroke , Bethesda, Maryland.
Steven Broglio4 University of Michigan , Ann Arbor, Michigan.
Robert Cantu5 Boston University School of Medicine , Boston, Massachusetts.
David Cook6 VA Puget Sound Health Care System , Seattle, Washington.
Uade Olaghere da Silva7 Naval Medical Research Center , San Diego, California.
Dara Dickstein8 Icahn School of Medicine at Mount Sinai , New York, New York.
Gregory Elder9 James J. Peters VA Medical Center , Bronx, New York.
Elizabeth Fudge10 Office of the Assistant Secretary of Defense , Health Affairs, Falls Church, Virginia.
Sam Gandy8 Icahn School of Medicine at Mount Sinai , New York, New York.
Jessica Gill12 National Institutes of Health , Bethesda, Maryland.
John F Glenn13 US Army Medical Research and Materiel Command , Fort Detrik, Maryland.
Raj K Gupta13 US Army Medical Research and Materiel Command , Fort Detrik, Maryland.
Sidney Hinds14 Defense and Veterans Brain Injury Center , Rockville, Maryland.
Stuart Hoffman15 Department of Veterans Affairs, Washington, DC.
Theresa Lattimore10 Office of the Assistant Secretary of Defense , Health Affairs, Falls Church, Virginia.
Alexander Lin16 Brigham and Women's Hospital , Harvard Medical School, Boston, Massachusetts.
Kun Ping Lu17 Beth Israel Deaconess Medical Center , Harvard Medical School, Boston, Massachusetts.
Joseph Maroon18 University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania.
David Okonkwo18 University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania.
Daniel Perl1 Uniformed Services University of the Health Sciences , Bethesda, Maryland.
Meghan Robinson19 VA Boston Healthcare System , Boston, Massachusetts.
Charles Rosen20 Department of Neurosurgery, West Virginia University , Morgantown, West Virginia.
Douglas Smith21 University of Pennsylvania , Philadelphia, Pennsylvania.

Funding

Development of Therapeutic Antibody for Traumatic Brain InjuryU01NS096835 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ZEIDEL, MARK L. · 2017 to 2021
$5.1M
Drug Discovery against the Early, Secreted and Toxic Tau in Alzheimer's DiseaseR01AG046319 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LU, KUN PING · 2014 to 2018
$1.8M
The role of glia dysfunction in the neurodegenerative processes induced by blastI01BX002311 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI COOK, DAVID G · 2014 to 2021
–
The Neurobiology of Blast-Related Brain Injury in a Rat Model of mTBII01RX000996 · VA · JAMES J PETERS VA MEDICAL CENTER · PI ELDER, GREGORY A. · 2014 to 2018
–
BLRD VA I01 BX002311NIA NIH HHS R01 AG046319NINDS NIH HHS U01 NS096835RRD VA I01 RX000996
6 · The paper itself

Abstract

Blast-related traumatic brain injury (TBI) is a signature injury of recent military conflicts, leading to increased Department of Defense (DoD) interest in its potential long-term effects, such as chronic traumatic encephalopathy (CTE). The DoD Blast Injury Research Program Coordinating Office convened the 2015 International State-of-the-Science Meeting to discuss the existing evidence regarding a causal relationship between TBI and CTE. Over the course of the meeting, experts across government, academia, and the sports community presented cutting edge research on the unique pathological characteristics of blast-related TBI, blast-related neurodegenerative mechanisms, risk factors for CTE, potential biomarkers for CTE, and treatment strategies for chronic neurodegeneration. The current paper summarizes these presentations. Although many advances have been made to address these topics, more research is needed to establish the existence of links between the long-term effects of single or multiple blast-related TBI and CTE.

Indexed as

Blast InjuriesBrain Injuries, TraumaticChronic Traumatic EncephalopathyMilitary MedicineHumansWarfareblast injurychronic traumatic encephalopathyneurodegenerationrepetitive head traumatraumatic brain injury

Identifiers

PMID28937955
PMCPMC5695753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.