Evidence map›Paper›PMID 28937873›Full record

ArticleEndocrine research2018

Effect of parathyroidectomy on osteopontin and undercarboxylated osteocalcin in patients with primary hyperparathyroidism.

Raelene E Maser, M James Lenhard, Ryan T Pohlig, P Babu Balagopal, Raafat Abdel-Misih

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05556499 (Interactions Between Bone and Parathyroid Tumors in Patiens With Primary Hyperparathyroidism), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05556499 unknown statusnot on this mapstarted 2022, after this paper: background citation

Interactions Between Bone and Parathyroid Tumors in Patiens With Primary Hyperparathyroidism (The PARABONE Study)

TypeobservationalSponsorI.R.C.C.S Ospedale Galeazzi-Sant'AmbrogioRan2022 to 2026Enrolled100ConditionsHyperparathyroidism, Primary, Osteoporosis, Parathyroid NeoplasmsArmsBiomarker assays
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Raelene E Masera Department of Medical Laboratory Sciences , University of Delaware , Newark , DE , USA.
M James Lenhardb Diabetes and Metabolic Research Center , Christiana Care Health System , Newark , DE , USA.
Ryan T Pohligd Biostatistics Core Facility , University of Delaware , Newark , DE , USA.
P Babu Balagopale Biomedical Research and Analysis Laboratory , Nemours Children's Specialty Care and Mayo Clinic College of Medicine , Jacksonville , FL , USA.
Raafat Abdel-Misihf Department of Surgery , Christiana Care Health System , Newark , DE , USA.
Christiana Care Health System · USUniversity of Delaware · USMayo Clinic in Florida · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

purposeSurgical treatment for primary hyperparathyroidism (PHPT) improves bone metabolism. Osteocalcin (OC) and its undercarboxylated form (ucOC) are associated with bone and energy metabolism. Osteopontin (OPN), a multifunctional protein expressed in bone, is involved in resorption, along with β-carboxyl-terminal cross-linking telopeptide of type 1 collagen (β-CTX), and osteoprotegerin (OPG). Our aim was to investigate these biomarkers of bone metabolism in patients with PHPT.

methodsWe examined 30 individuals with PHPT, in a clinical research facility, before and 1 month following parathyroidectomy. Circulating levels of OC, ucOC, OPN, β-CTX, and OPG were examined as bone biomarkers along with inflammatory markers (e.g., interleukin-6 [IL-6], lipocalin-2), insulin resistance (i.e., homeostasis model assessment for insulin resistance [HOMA-IR]), adiposity (i.e., leptin, adiponectin), PTH, calcium, 25-hydroxyvitamin D, creatinine, and demographics.

resultsParticipants (27 females/3 males) were 60 ± 9 (mean±SD) years old. There was a significant reduction of ucOC (7.9 ± 5.1 [median±SIQR] vs. 6.6 ± 3.7 ng/mL, p = 0.022) and OPN (75.4 ± 14.5 vs. 54.5 ± 9.2 ng/mL, p < 0.001) pre- versus post-parathyroidectomy. There were no univariate differences postoperatively for IL-6, HOMA-IR, leptin, or adiponectin. Regression analysis showed that postoperative levels of adiponectin, IL-6, and OPN were significantly associated with ucOC, while adjusting for PTH and albumin corrected calcium levels (model R

conclusionThe lower 1-month postoperative OPN and ucOC levels in PHPT seem to indicate reduced bone resorption. Decreased ucOC levels may also suggest lower energy demands postoperatively.

Indexed as

ParathyroidectomyAdiponectinAgedFemaleFollow-Up StudiesHumansHyperparathyroidism, PrimaryInsulin ResistanceInterleukin-6LeptinMaleMiddle AgedOsteocalcinOsteopontinOsteoprotegerinAdiponectinADIPOQ protein, humanIL6 protein, humanInterleukin-6LeptinOsteocalcinOsteopontinOsteoprotegerinSPP1 protein, humanTNFRSF11B protein, humanOsteopontinparathyroidectomyprimary hyperparathyroidismundercarboxylated osteocalcin

Identifiers

PMID28937873
PMCPMC6082020
OpenAlexW2757366681

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.