Evidence map›Paper›PMID 28937604›Full record

ArticleToxins2017

Asymmetric Cryo-EM Structure of Anthrax Toxin Protective Antigen Pore with Lethal Factor N-Terminal Domain.

Alexandra J Machen, Narahari Akkaladevi, Caleb Trecazzi, Pierce T O'Neil, Srayanta Mukherjee, Yifei Qi, Rebecca Dillard, Wonpil Im, Edward P Gogol, Tommi A White and 1 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Alexandra J MachenDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. amachen@kumc.edu.
Narahari AkkaladeviDepartment of Biochemistry, University of Missouri, Columbia, MO 65211, USA. akkaladevin@missouri.edu.
Caleb TrecazziDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. ctrecazzi@kumc.edu.ORCID 0000-0001-6736-8676
Pierce T O'NeilDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. poneil@kumc.edu.
Srayanta MukherjeeDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. srayanta@gmail.com.
Yifei QiDepartments of Biological Sciences and Bioengineering, Lehigh University, Bethlehem, PA 18015, USA. yfqi@chem.ecnu.edu.cn.
Rebecca DillardNational Center for Macromolecular Imaging, Baylor University, Houston TX 77030, USA. rdillard@gmail.com.
Wonpil ImDepartments of Biological Sciences and Bioengineering, Lehigh University, Bethlehem, PA 18015, USA. woi216@lehigh.edu.
Edward P GogolDepartment of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110, USA. gogole@umkc.edu.
Tommi A WhiteDepartment of Biochemistry, University of Missouri, Columbia, MO 65211, USA. whiteto@missouri.edu.
Mark T FisherDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. mfisher1@kumc.edu.
University of Kansas Medical Center · USLehigh University · USUniversity of Missouri · USBaylor University · USUniversity of Missouri–Kansas City · US

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHOU, MING · 2010 to 2017
$31.9M
3 D ELECTRON MICROSCOPY OF MACROMOLECULES (5P41RR002250-27)P41GM103832 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2012 to 2019
$15.1M
PHARMACEUTICAL ASPECTS OF BIOTECHNOLOGY TRAININGT32GM008359 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI SIAHAAN, TERUNA J., VOLKIN, DAVID · 1989 to 2018
$5.0M
CryoEM analysis of Anthrax Toxin Pore ComplexesR01AI090085 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI FISHER, MARK T · 2011 to 2013
$948k
NIAID NIH HHS R01 AI090085NIGMS NIH HHS P41 GM103832NIGMS NIH HHS T32 GM008359NIGMS NIH HHS U54 GM087519
6 · The paper itself

Abstract

The anthrax lethal toxin consists of protective antigen (PA) and lethal factor (LF). Understanding both the PA pore formation and LF translocation through the PA pore is crucial to mitigating and perhaps preventing anthrax disease. To better understand the interactions of the LF-PA engagement complex, the structure of the LF

Indexed as

AnthraxAntigens, BacterialBacterial ToxinsCryoelectron MicroscopyMolecular Dynamics SimulationProtein Structure, Tertiaryanthrax toxinAntigens, BacterialBacterial Toxinsanthrax toxincryo-EMcryoSPARClethal factornanodiscpore formationprotective antigentranslocation

Identifiers

PMID28937604
PMCPMC5666345
OpenAlexW2760646424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.