Spatiotemporal Control of Doxorubicin Delivery from "Stealth-Like" Prodrug Micelles.

Li Kong, Dimitrios Poulcharidis, Gregory F Schneider, Frederick Campbell, Alexander Kros

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Systematic review and meta-analysis of randomized controlled trials: low-intensity extracorporeal shockwave therapy (Li-ESWT) for erectile dysfunction after radical prostatectomy.International urology and nephrology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li KongSupramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry, Einsteinweg 55, 2333 CC Leiden, The Netherlands. l.kong@chem.leidenuniv.nl.

Dimitrios PoulcharidisSupramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry, Einsteinweg 55, 2333 CC Leiden, The Netherlands. d.poulcharidis@chem.leidenuniv.nl.

Gregory F SchneiderSupramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry, Einsteinweg 55, 2333 CC Leiden, The Netherlands. g.f.schneider@chem.leidenuniv.nl.

Frederick CampbellSupramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry, Einsteinweg 55, 2333 CC Leiden, The Netherlands. f.campbell@chem.leidenuniv.nl.

Alexander KrosSupramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry, Einsteinweg 55, 2333 CC Leiden, The Netherlands. a.kros@chem.leidenuniv.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the treatment of cancer, targeting of anticancer drugs to the tumor microenvironment is highly desirable. Not only does this imply accurate tumor targeting but also minimal drug release en route to the tumor and maximal drug release once there. Here we describe high-loading, "stealth-like" doxorubicin micelles as a pro-drug delivery system, which upon light activation, leads to burst-like doxorbicin release. Through this approach, we show precise spatiotemporal control of doxorubicin delivery to cells in vitro.

Indexed as

Drug Delivery SystemsMicellesDoxorubicinDrug LiberationHeLa CellsHumansLightProdrugsDoxorubicinMicellesProdrugsdoxorubicinlight activationmicellesprodrugs

Identifiers

PMID28937592

DOI10.3390/ijms18102033

PMCPMC5666715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.