ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)
Cerebral Oxygenation of Premature Lambs Supported by an Artificial Placenta.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Physiology-Mimicking Microfluidic Oxygenator with Good Hemocompatibility forMicromachines · 2026Article
- Extracorporeal Support Vascular Access: 3D Printing Custom Cannulas.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes.Children (Basel, Switzerland) · 2025Review
- Artificial womb technology - A more physiologic solution to treating extreme prematurity.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Total liquid ventilation in an ovine model of extreme prematurity: a randomized study.Pediatric research · 2024Article
- Extracorporeal life support without systemic anticoagulation: a nitric oxide-based non-thrombogenic circuit for the artificial placenta in an ovine model.Pediatric research · 2024Article
- The artificial placenta and EXTEND technologies: one of these things is not like the other.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Ethical challenges in first-in-human trials of the artificial placenta and artificial womb: not all technologies are created equally, ethically.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Aeration strategy at birth does not impact carotid haemodynamics in preterm lambs.Pediatric research · 2023Article
- An Artificial Placenta Experimental System in Sheep: Critical Issues for Successful Transition and Survival up to One Week.Biomedicines · 2023Article
- Impact of the Addition of a Centrifugal Pump in a Preterm Miniature Pig Model of the Artificial Placenta.Frontiers in physiology · 2022Article
- Development of an artificial placenta for support of premature infants: narrative review of the history, recent milestones, and future innovation.Translational pediatrics · 2021Review
- Achieving sustained extrauterine life: Challenges of an artificial placenta in fetal pigs as a model of the preterm human fetus.Physiological reports · 2021Article
- The Various Oximetric Techniques Used for the Evaluation of Blood Oxygenation.Sensors (Basel, Switzerland) · 2020Review
- Effects of an artificial placenta on brain development and injury in premature lambs.Journal of pediatric surgery · 2018Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
An artificial placenta (AP) using venovenous extracorporeal life support (VV-ECLS) could represent a paradigm shift in the treatment of extremely premature infants. However, AP support could potentially alter cerebral oxygen delivery. We assessed cerebral perfusion in fetal lambs on AP support using near-infrared spectroscopy (NIRS) and carotid arterial flow (CAF). Fourteen premature lambs at estimated gestational age (EGA) 130 days (term = 145) underwent cannulation of the right jugular vein and umbilical vein with initiation of VV-ECLS. An ultrasonic flow probe was placed around the right carotid artery (CA), and a NIRS sensor was placed on the scalp. Lambs were not ventilated. CAF, percentage of regional oxygen saturation (rSO2) as measured by NIRS, hemodynamic data, and blood gases were collected at baseline (native placental support) and regularly during AP support. Fetal lambs were maintained on AP support for a mean of 55 ± 27 hours. Baseline rSO2 on native placental support was 40% ± 3%, compared with a mean rSO2 during AP support of 50% ± 11% (p = 0.027). Baseline CAF was 27.4 ± 5.4 ml/kg/min compared with an average CAF of 23.7 ± 7.7 ml/kg/min during AP support. Cerebral fractional tissue oxygen extraction (FTOE) correlated negatively with CAF (r = -0.382; p < 0.001) and mean arterial pressure (r = -0.425; p < 0.001). FTOE weakly correlated with systemic O2 saturation (r = 0.091; p = 0.017). Cerebral oxygenation and blood flow in premature lambs are maintained during support with an AP. Cerebral O2 extraction is inversely related to carotid flow and is weakly correlated with systemic O2 saturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.