Evidence map›Paper›PMID 28937310›Full record

Trial reportMultiple sclerosis (Houndmills, Basingstoke, England)2018

Remotely supervised transcranial direct current stimulation for the treatment of fatigue in multiple sclerosis: Results from a randomized, sham-controlled trial.

Leigh E Charvet, Bryan Dobbs, Michael T Shaw, Marom Bikson, Abhishek Datta, Lauren B Krupp

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Multiple sclerosis (Houndmills, Basingstoke, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 68 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03833583 nacompletednot on this mapstarted 2019, after this paper: background citation

Transcranial Direct Current Stimulation (tDCS) to Reduce Craving in Cocaine Addiction

TypeinterventionalSponsorSoterix MedicalRan2019 to 2019Enrolled25ConditionsCocaine Use Disorder, Cocaine DependenceArmsSoterix Medical mini-CT tDCS stimulator
NCT04994821 phase2completednot on this mapstarted 2020, after this paper: background citation

A Phase 2 Study to Investigate Use of Transcranial Direct Current Stimulation (tDCS) to Reduce Craving in Cocaine Addiction

TypeinterventionalSponsorSoterix MedicalRan2020 to 2022Enrolled60ConditionsCocaine Use Disorder, Cocaine DependenceArmstranscranial direct current stimulator (tDCS), Cognitive Reappraisal
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  3. Interventions for multidimensional aspects of breast cancer-related fatigue: a meta-analytic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leigh E CharvetDepartment of Neurology, NYU Langone Medical Center, New York, NY, USA.
Bryan DobbsDepartment of Neurology, NYU Langone Medical Center, New York, NY, USA.
Michael T ShawDepartment of Neurology, NYU Langone Medical Center, New York, NY, USA.
Marom BiksonDepartment of Biomedical Engineering, The City University of New York, New York, NY, USA.
Abhishek DattaSoterix Medical, New York, NY, USA.
Lauren B KruppDepartment of Neurology, NYU Langone Medical Center, New York, NY, USA.

Funding

A tool-box to control and enhance tDCS spatial precisionR01MH111896 · NIMH · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2016 to 2019
$2.2M
NIMH NIH HHS R01 MH111896
6 · The paper itself

Abstract

backgroundFatigue is a common and debilitating feature of multiple sclerosis (MS) that remains without reliably effective treatment. Transcranial direct current stimulation (tDCS) is a promising option for fatigue reduction. We developed a telerehabilitation protocol that delivers tDCS to participants at home using specially designed equipment and real-time supervision (remotely supervised transcranial direct current stimulation (RS-tDCS)).

objectiveTo evaluate whether tDCS can reduce fatigue in individuals with MS.

methodsDorsolateral prefrontal cortex left anodal tDCS was administered using a RS-tDCS protocol, paired with 20 minutes of cognitive training. Here, two studies are considered. Study 1 delivered 10 open-label tDCS treatments (1.5 mA; n = 15) compared to a cognitive training only condition ( n = 20). Study 2 was a randomized trial of active (2.0 mA, n = 15) or sham ( n = 12) delivered for 20 sessions. Fatigue was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS)-Fatigue Short Form. RESULTS AND

conclusionIn Study 1, there was modest fatigue reduction in the active group (-2.5 ± 7.4 vs -0.2 ± 5.3, p = 0.30, Cohen's d = -0.35). However, in Study 2 there was statistically significant reduction for the active group (-5.6 ± 8.9 vs 0.9 ± 1.9, p = 0.02, Cohen's d = -0.71). tDCS is a potential treatment for MS-related fatigue.

Indexed as

Cognition DisordersFatigueFeasibility StudiesFemaleHumansMaleMemory, Short-TermMultiple SclerosisPrefrontal CortexTranscranial Direct Current StimulationTreatment OutcomeFatiguemultiple sclerosistDCStelerehabilitationtEStranscranial direct current stimulation

Identifiers

PMID28937310
PMCPMC5975187

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.