Evidence map›Paper›PMID 28936917›Full record

ArticleStatistical methods in medical research2019

Scalable collaborative targeted learning for high-dimensional data.

Cheng Ju, Susan Gruber, Samuel D Lendle, Antoine Chambaz, Jessica M Franklin, Richard Wyss, Sebastian Schneeweiss, Mark J van der Laan

Abstract read
In one paragraph

Article in Statistical methods in medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cheng Ju1 University of California, Berkeley, CA, USA.ORCID 0000-0001-7585-6266
Susan Gruber2 Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA.
Samuel D Lendle1 University of California, Berkeley, CA, USA.
Antoine Chambaz1 University of California, Berkeley, CA, USA.
Jessica M Franklin3 Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Womens Hospital and Harvard Medical School, Boston, MA, USA.
Richard Wyss3 Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Womens Hospital and Harvard Medical School, Boston, MA, USA.
Sebastian Schneeweiss3 Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Womens Hospital and Harvard Medical School, Boston, MA, USA.
Mark J van der Laan1 University of California, Berkeley, CA, USA.

Funding

Targeted Learning using adaptive designs for HIV Epidemic control in East AfricaR01AI074345 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI PETERSEN, MAYA LIV, VANDERLAAN, MARK J · 2007 to 2023
$6.6M
NIAID NIH HHS R01 AI074345
6 · The paper itself

Abstract

Robust inference of a low-dimensional parameter in a large semi-parametric model relies on external estimators of infinite-dimensional features of the distribution of the data. Typically, only one of the latter is optimized for the sake of constructing a well-behaved estimator of the low-dimensional parameter of interest. Optimizing more than one of them for the sake of achieving a better bias-variance trade-off in the estimation of the parameter of interest is the core idea driving the general template of the collaborative targeted minimum loss-based estimation procedure. The original instantiation of the collaborative targeted minimum loss-based estimation template can be presented as a greedy forward stepwise collaborative targeted minimum loss-based estimation algorithm. It does not scale well when the number p of covariates increases drastically. This motivates the introduction of a novel instantiation of the collaborative targeted minimum loss-based estimation template where the covariates are pre-ordered. Its time complexity is

Indexed as

Models, StatisticalAgedAlgorithmsAnti-Inflammatory Agents, Non-SteroidalComputer SimulationGastrointestinal HemorrhageHumansObservational Studies as TopicPeptic UlcerPeptic Ulcer PerforationPropensity ScoreAnti-Inflammatory Agents, Non-Steroidalelectronic healthcare databasehigh-dimensional dataObservational studypropensity scoretargeted minimum loss-based estimationvariable selection

Identifiers

PMID28936917
PMCPMC6086775

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.