ArticleThe British journal of radiology2018
Fat fraction mapping using magnetic resonance imaging: insight into pathophysiology.
Article in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Liver Fat Quantification and Steatosis Grading in Fatty Liver Disease by Magnetic Resonance Imaging: Systematic Review and Meta-Analysis.Journal of gastroenterology and hepatology · 2025Pooled it
- Ultrasound predicts skeletal muscle fat infiltration in healthy middle-aged and young adults: Validation against MRI.Experimental physiology · 2026Trial
- Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 d of bed rest.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Trial
- MRI-Determined Muscle Fat Fractions and Contractile Volumes in Myotonic Dystrophy Type 2.Muscle & nerve · 2026Article
- Integrating kidney imaging for risk prediction, therapeutic monitoring, and prognostication across the kidney disease spectrum: a review of emerging evidence.Clinical kidney journal · 2026Review
- Reference Methods for Measuring Skeletal Muscle Mass: A Critical Perspective.Journal of cachexia, sarcopenia and muscle · 2026Review
- Validation of Velacur Liver Stiffness and Attenuation in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease.Gastro hep advances · 2026Article
- Potential Role of Imaging in the Evaluation of Adiposity and Approval of Anti-Obesity Drugs.Korean journal of radiology · 2026Review
- Clinical indices and anthropometric measures for magnetic resonance imaging-defined visceral adiposity across the hypercortisolism spectrum.Frontiers in endocrinology · 2026Article
- Musculoskeletal manifestations of sickle cell disease: an imaging perspective.Skeletal radiology · 2025Review
- Leveraging dixon-based magnetic resonance imaging for pelvic bone marrow imaging in radiotherapy.Physics and imaging in radiation oncology · 2025Article
- Novel Strategies to Conquer Residual Adiposity Risk in Cardiovascular Disease.Current atherosclerosis reports · 2025Review
- Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk.Nature communications · 2025Article
- Paraspinal myosteatosis is associated with COPD: a cross-sectional MRI analysis from the population-based KORA cohort.Respiratory research · 2025Article
- Radiologic correlation with fatty liver and adrenal adenoma using dual echo chemical shift magnetic resonance imaging.Abdominal radiology (New York) · 2025Article
- Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantification of Bone Marrow Aging and Radiation Effects in Mice.Bioengineering (Basel, Switzerland) · 2025Article
- Liver magnetic resonance spectroscopy as an alternative for evaluating Niemann-Pick C disease progression.RSC advances · 2025Article
- Review
- A visual marker for early atrophy of the supraspinatus muscle on conventional MRI: introduction of the blackbird sign.European radiology · 2025Article
- Age-related differences in intramuscular fat distribution: spatial quantification in human ankle plantar flexors.Frontiers in bioengineering and biotechnology · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Adipose cells have traditionally been viewed as a simple, passive energy storage depot for triglycerides. However, in recent years it has become clear that adipose cells are highly physiologically active and have a multitude of endocrine, metabolic, haematological and immune functions. Changes in the number or size of adipose cells may be directly implicated in disease (e.g. in the metabolic syndrome), but may also be linked to other pathological processes such as inflammation, malignant infiltration or infarction. MRI is ideally suited to the quantification of fat, since most of the acquired signal comes from water and fat protons. Fat fraction (FF, the proportion of the acquired signal derived from fat protons) has, therefore, emerged as an objective, image-based biomarker of disease. Methods for FF quantification are becoming increasingly available in both research and clinical settings, but these methods vary depending on the scanner, manufacturer, imaging sequence and reconstruction software being used. Careful selection of the imaging method-and correct interpretation-can improve the accuracy of FF measurements, minimize potential confounding factors and maximize clinical utility. Here, we review methods for fat quantification and their strengths and weaknesses, before considering how they can be tailored to specific applications, particularly in the gastrointestinal and musculoskeletal systems. FF quantification is becoming established as a clinical and research tool, and understanding the underlying principles will be helpful to both imaging scientists and clinicians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.