Evidence map›Paper›PMID 28936784›Full record

ArticleProtein & cell2017

Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism.

Sensen Zhang, Ningning Li, Wenwen Zeng, Ning Gao, Maojun Yang

Open access · diamondAbstract read
In one paragraph

Article in Protein & cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. A Structural Overview of TRPML1 and the TRPML Family.Handbook of experimental pharmacology · 2023
    Article
  6. Atomic insights into ML-SI3 mediated human TRPML1 inhibition.Structure (London, England : 1993) · 2021
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Opening TRPP2 (Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  12. Review
  13. Transient Receptor Potential Channels and Calcium Signaling.Cold Spring Harbor perspectives in biology · 2019
    Review
  14. Review
  15. Structural Variability in the RLR-MAVS Pathway and Sensitive Detection of Viral RNAs.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2019
    Review
  16. Endolysosomal CaCancers · 2018
    Review
  17. Article
  18. Structural basis for PtdInsPNature communications · 2018
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sensen ZhangMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Ningning LiState Key Laboratory of Membrane Biology, Peking-Tsinghua Center for Life Sciences, School of Life Science, Peking University, Beijing, 100871, China.
Wenwen ZengInstitute for Immunology and School of Medicine, Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Ning GaoState Key Laboratory of Membrane Biology, Peking-Tsinghua Center for Life Sciences, School of Life Science, Peking University, Beijing, 100871, China. gaon@pku.edu.cn.
Maojun YangMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China. maojunyang@tsinghua.edu.cn.
Center for Life Sciences · CNPeking University · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TRPML1 channel is a non-selective group-2 transient receptor potential (TRP) channel with Ca

Indexed as

EndocytosisAnimalsCalciumCryoelectron MicroscopyEndosomesGene ExpressionHEK293 CellsHumansHydrogen-Ion ConcentrationLysosomesMiceModels, BiologicalMucolipidosesNanostructuresPhosphatidylinositolsTransgenesCalciumMcoln1 protein, mousePhosphatidylinositolsTransient Receptor Potential Channelscombined regulation mechanismmTRPML1mucolipidosis type IVstructual comparisons

Identifiers

PMID28936784
PMCPMC5676595
OpenAlexW2759937219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.